OTTMUSG00000016823 Activators
Proline-rich protein 33 (PR33) is a crucial protein involved in various cellular processes. It plays a significant role in cell signaling, adhesion, and cytoskeletal organization. PR33 is known to interact with various other proteins and participate in complex molecular pathways within the cell. Activation of PR33 can be achieved through both direct and indirect mechanisms. Direct activators like Forskolin, 8-Bromo-cAMP, Phorbol 12-myristate 13-acetate (PMA), Ionomycin, and Sodium orthovanadate act by directly stimulating PR33 or its downstream signaling pathways. Forskolin, for instance, activates PR33 by stimulating adenylyl cyclase, leading to increased cyclic AMP (cAMP) levels, which in turn activate PR33.
On the other hand, indirect activators like Resveratrol, Epigallocatechin gallate (EGCG), Dexamethasone, Trichostatin A, Sodium butyrate, Retinoic acid, and 2-Aminoethoxydiphenyl borate (2-APB) modulate cellular pathways that indirectly influence PR33 activation. For example, Resveratrol indirectly activates PR33 by modulating the Sirtuin 1 (SIRT1) pathway, which enhances deacetylation of histones and promotes PR33 gene expression. These activators collectively contribute to the regulation of PR33 activity, allowing it to perform its essential functions within the cell. Understanding the specific mechanisms of activation is crucial in unraveling the intricate roles that PR33 plays in cellular processes, ultimately advancing our knowledge of its biological significance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Proline-rich protein 33 indirectly by modulating the Sirtuin 1 (SIRT1) pathway, which enhances deacetylation of histones and promotes gene expression, including PR33. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP directly activates Proline-rich protein 33 by mimicking cyclic AMP (cAMP), thereby stimulating downstream signaling pathways and protein activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates Proline-rich protein 33 indirectly by inhibiting DNA methyltransferases, leading to demethylation of the PR33 promoter region and increased gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) directly activates Proline-rich protein 33 by activating protein kinase C (PKC), which in turn phosphorylates PR33 and enhances its activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone activates Proline-rich protein 33 indirectly by modulating the glucocorticoid receptor (GR) pathway, leading to increased PR33 transcription and protein levels. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate activates Proline-rich protein 33 directly by inhibiting protein tyrosine phosphatases (PTPs), resulting in increased phosphorylation and PR33 activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A activates Proline-rich protein 33 indirectly by inhibiting histone deacetylases (HDACs), leading to histone hyperacetylation and enhanced PR33 gene expression. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin directly activates Proline-rich protein 33 by increasing intracellular calcium levels, which activate calcium/calmodulin-dependent kinases and stimulate PR33. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate activates Proline-rich protein 33 indirectly by inhibiting HDACs, similar to Trichostatin A, resulting in enhanced gene expression and PR33 activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates Proline-rich protein 33 indirectly by binding to retinoic acid receptors (RARs), leading to transcriptional regulation and increased PR33 levels. | ||||||