OTTMUSG00000002543 Activators

Keratin-associated protein 4-2, encoded by the Gm11595 gene, is a crucial component involved in intracellular signaling pathways, particularly those dependent on cyclic adenosine monophosphate (cAMP). This protein plays a pivotal role in regulating various cellular processes and is integral to the modulation of cellular responses to external stimuli. The activation of keratin-associated protein 4-2 is intricately linked to the modulation of cAMP levels within the cell. Several chemical activators, including Forskolin, Isoproterenol, and Epinephrine, stimulate the protein by interacting with adrenergic receptors or inhibiting phosphodiesterases, leading to increased intracellular cAMP levels and functional activation. Caffeine and IBMX activate the protein by preventing cAMP degradation, thereby promoting its functional activation.

Furthermore, Glucagon, Prostaglandin E2 (PGE2), and Adenosine triphosphate (ATP) activate keratin-associated protein 4-2 through specific receptor binding, initiating downstream signaling events that result in elevated cAMP levels and functional activation. Norepinephrine and Terbutaline activate the protein by binding to adrenergic receptors, leading to cAMP production and functional activation. Additionally, 8-Bromo-cAMP directly mimics the effects of cAMP, initiating downstream pathway activation and functional activation of keratin-associated protein 4-2. Adenylyl Cyclase Activator directly stimulates adenylate cyclase, resulting in increased cAMP levels and functional activation of the protein. In summary, keratin-associated protein 4-2 is a key player in cAMP-dependent intracellular signaling pathways. Its activation is achieved through a variety of chemical activators that modulate cAMP levels, enabling the protein to participate in essential cellular processes and coordinate cellular responses to external stimuli. These activators serve as critical components in regulating intracellular signaling cascades, emphasizing the importance of keratin-associated protein 4-2 in cellular communication and signaling networks.