OR5H14 Inhibitors
OR5H14 inhibitors are chemical compounds specifically designed to modulate the activity of the OR5H14 protein, a member of the olfactory receptor (OR) family. Olfactory receptors are G-protein coupled receptors (GPCRs) that are primarily involved in detecting odor molecules in the environment. The OR5H14 receptor is encoded by the OR5H14 gene and is expressed in olfactory sensory neurons located in the nasal epithelium. Like other olfactory receptors, OR5H14 is responsible for binding to specific ligands, which initiate a cascade of intracellular signaling processes through the activation of G-proteins. The result is the generation of action potentials that relay information to the brain, allowing the perception of certain smells. Inhibitors targeting the OR5H14 receptor function by preventing or reducing the binding of natural ligands, thus attenuating or completely blocking the receptor's signal transduction.
The inhibition of OR5H14 can be achieved through various chemical mechanisms, such as competitive binding at the ligand-binding site or allosteric modulation, where inhibitors bind to a different part of the receptor to induce conformational changes. Structural studies of OR5H14 and its inhibitors are crucial for understanding the binding affinity, receptor-ligand interactions, and the precise mechanism of inhibition. Researchers often utilize molecular docking, crystallography, and computational modeling to investigate how these inhibitors affect the receptor's conformation and signal transduction. These insights are valuable in the design and refinement of more potent or selective OR5H14 inhibitors. Beyond structural considerations, the development of these inhibitors often involves optimizing their physicochemical properties to enhance receptor specificity, binding kinetics, and stability under experimental conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamic Aldehyde interacts with Olfactory receptor 5H14 by binding competitively to the same site as natural odorants. This binding inhibits the receptor's ability to respond to its specific ligands, thus directly inhibiting the olfactory signal transduction pathway initiated by this receptor. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, although primarily known for activating certain heat-sensitive receptors, has been shown to inhibit Olfactory receptor 5H14 by allosterically modifying the receptor conformation. This modification inhibits the receptor's ability to bind to its natural odorant molecules, leading to inhibition of its olfactory signaling function. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol acts on Olfactory receptor 5H14 by inducing a cooling sensation that can inhibit the receptor's normal response to odorants. This inhibitory effect is achieved through menthol's interaction with the receptor, altering its conformation and thereby reducing its ability to initiate olfactory signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol inhibits Olfactory receptor 5H14 by binding to the receptor's active site, where it competes with natural odorant molecules for binding. This competitive inhibition prevents the receptor from being activated by its natural ligands, thus inhibiting the olfactory signaling pathway. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine inhibits Olfactory receptor 5H14 by blocking the receptor's ion channels, which are essential for initiating the electrical signal that results from receptor activation. This blockade prevents the receptor from transmitting olfactory signals to the brain, directly inhibiting its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions inhibit Olfactory receptor 5H14 by binding to specific sites on the receptor, which leads to a conformational change that reduces receptor sensitivity to odorants. This inhibition of receptor activity directly impacts the olfactory signaling pathway. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate inhibits Olfactory receptor 5H14 by interacting with the receptor's metal-binding sites, leading to a decrease in receptor activity. This interaction inhibits the receptor's ability to bind its natural ligands, directly reducing olfactory signal transduction. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine inhibits Olfactory receptor 5H14 through a mechanism that involves the blockade of receptor's active sites, preventing the binding of odorant molecules. This inhibition directly impacts the receptor's ability to transmit olfactory signals. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal inhibits Olfactory receptor 5H14 by competing with natural odorants for binding sites on the receptor. This competition inhibits the receptor's activation and subsequent olfactory signaling, directly impacting olfactory perception. | ||||||