OR2AG2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin selectively binds to the transient receptor potential vanilloid 1 (TRPV1) receptor, which can lead to an influx of calcium ions. Elevated intracellular calcium can down-regulate G-protein-coupled receptor (GPCR) activity, including OR2AG2, through calcium-mediated desensitization mechanisms. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to alkalinize intracellular vesicles, impairing endosomal acidification. This can affect the trafficking and recycling of GPCRs, such as OR2AG2, thereby reducing its presence on the cell surface and its functional activity. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine acts as a sodium channel blocker, which can dampen neuronal excitability. Reduced neuronal firing can decrease the release of neurotransmitters that regulate GPCR activity, thus potentially diminishing OR2AG2 signaling indirectly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can activate protein kinase A (PKA), which has been shown to phosphorylate and desensitize GPCRs. This could lead to the functional inhibition of OR2AG2 by promoting its desensitization. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-adrenergic receptor antagonist that can down-regulate cAMP production. This might lead to a reduction in PKA activity, which can influence the phosphorylation state and activity of various GPCRs, potentially including OR2AG2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to disrupt lipid rafts in cellular membranes. Since GPCRs, including OR2AG2, are often localized in these rafts for proper signaling, disruption can inhibit the functional activity of the receptor. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol interferes with the activation of the PI3K/Akt signaling pathway, which can regulate GPCR internalization and recycling. Inhibition of this pathway can decrease the functional activity of receptors like OR2AG2 by affecting their cellular trafficking. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, leading to reduced cholesterol biosynthesis. Since cholesterol is integral to cell membrane structure where GPCRs reside, reducing its levels can alter membrane fluidity and potentially inhibit GPCR function, including OR2AG2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent phosphorylation of proteins involved in GPCR signaling. This may lead to a reduction in OR2AG2 signaling by affecting the receptor's conformation or its association with G proteins. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, may modulate intracellular calcium levels that are crucial for GPCR function. Lower calcium levels can result in reduced OR2AG2 activity due to decreased receptor sensitivity or altered G protein coupl | ||||||