OR10G9 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
A local anesthetic and sodium channel blocker that inhibits voltage-gated sodium channels (Nav). By blocking Nav channels, lidocaine can suppress the action potentials in neurons, including those that express OR10G9, leading to reduced neuronal excitability and decreased OR10G9 activity. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
An alkaloid that acts as a non-selective inhibitor of voltage-gated potassium channels. The inhibition of these channels by quinine can alter the repolarization phase of action potentials, potentially decreasing the frequency of action potentials in neurons expressing OR10G9. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
An inhibitor of various calcium channels, including voltage-gated and intracellular calcium channels. By limiting calcium influx, ruthenium red can decrease the activity of neurons, thus reducing OR10G9 signaling due to decreased neuronal excitability. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
A GABA_A receptor antagonist that blocks inhibitory neurotransmission mediated by GABA. By preventing GABA-induced inhibition, bicuculline can increase neuronal activity nonspecifically, but in the context of OR10G9, it could lead to the desensitization of OR10G9-expressing neurons due to sustained activity. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
A TRPV1 antagonist that can block capsaicin-induced activation of TRPV1. By inhibiting TRPV1, capsazepine can reduce neuropeptide release from sensory neurons, potentially diminishing the activity of OR10G9 by reducing modulatory neuropeptide signaling. | ||||||
Ethosuximide | 77-67-8 | sc-211431 | 1 g | $300.00 | ||
Primarily known as an antiepileptic drug that blocks T-type calcium channels. By reducing the activity of these channels, ethosuximide can diminish thalamic neuron oscillations, which may indirectly decrease OR10G9 signaling in the olfactory system. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
A drug that inhibits glutamatergic neurotransmission and modulates sodium channels. Riluzole's action can decrease excitatory neurotransmission and may lead to a reduction in OR10G9 activity by decreasing the overall excitability of neurons. | ||||||