Olr560 Activators
Chemical activators of Olr560 operate through a cascade of intracellular signaling events, predominantly involving the elevation of cyclic AMP (cAMP) levels and the activation of Protein Kinase A (PKA). Forskolin, a diterpene found in the Indian coleus plant, directly stimulates adenylyl cyclase, the enzyme responsible for converting ATP to cAMP. The increased cAMP levels activate PKA, which then phosphorylates target proteins, including Olr560, thereby modulating its activity. Similarly, Isoproterenol, a synthetic compound, functions as a beta-adrenergic agonist, also binding to beta-adrenergic receptors and stimulating adenylyl cyclase, which in turn elevates cAMP levels and leads to PKA activation. Histamine, through its interaction with H2 receptors, and PGE2 (Prostaglandin E2), via its EP receptors, both contribute to the activation of adenylyl cyclase, subsequently increasing cAMP and activating PKA, which can phosphorylate Olr560.
Moreover, neurotransmitters such as dopamine and adenosine facilitate Olr560 activation by engaging with their respective receptors, D1-like and A2A, which are positively coupled to adenylyl cyclase, thereby elevating cAMP and activating PKA. Glucagon, a peptide hormone, also binds to its receptor and activates adenylyl cyclase, following the same intracellular pathway leading to the potential phosphorylation of Olr560. Caffeine and IBMX (3-Isobutyl-1-methylxanthine) maintain elevated intracellular levels of cAMP by inhibiting phosphodiesterase, an enzyme that breaks down cAMP, thus leading to prolonged PKA activation and the subsequent phosphorylation of Olr560. Serotonin engages with its 5-HT receptors to increase cAMP levels, and catecholamines such as epinephrine and norepinephrine, through their action on adrenergic receptors, stimulate adenylyl cyclase activity, enhance cAMP production, activate PKA, and ultimately result in the phosphorylation and activation of Olr560.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors, stimulating adenylyl cyclase activity. This increases cAMP and subsequently activates PKA, which could phosphorylate and activate Olr560 as part of the downstream effects. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, engaging with H2 receptors, triggers adenylyl cyclase which results in a rise in cAMP levels. The increase in cAMP activates PKA, which in turn is known to phosphorylate and activate proteins like Olr560 within the relevant signaling cascade. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its EP receptors, which can activate adenylyl cyclase, thus increasing cAMP production. The rise in cAMP activates PKA, which may lead to the phosphorylation and activation of Olr560. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine acts through its D1-like receptors, which are coupled to adenylyl cyclase, enhancing the production of cAMP. Increased cAMP activates PKA, which could phosphorylate and activate Olr560 within its signaling pathway. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine binds to A2A receptors, which are positively linked to adenylyl cyclase, leading to an increase in cAMP. This elevation in cAMP activates PKA, which can then activate Olr560 by phosphorylation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a phosphodiesterase inhibitor, preventing the breakdown of cAMP. This results in sustained activation of PKA, which may lead to phosphorylation and activation of Olr560. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterase, leading to increased levels of cAMP and sustained activation of PKA, which could result in the phosphorylation and activation of Olr560. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Serotonin interacts with 5-HT receptors that are coupled to adenylyl cyclase, resulting in an increase in cAMP levels and activation of PKA. PKA can then potentially phosphorylate and activate Olr560 as part of the signal transduction pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, through its action on beta-adrenergic receptors, leads to the activation of adenylyl cyclase, an increase in cAMP levels, and subsequent activation of PKA. PKA may then phosphorylate and activate Olr560 as part of its signaling mechanism. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine, acting on both alpha and beta-adrenergic receptors, stimulates adenylyl cyclase, increasing cAMP levels and activating PKA. PKA is capable of phosphorylating and activating Olr560 in the context of its signaling pathway. | ||||||