Olfr859 Activators
Olfr859 is an olfactory receptor gene encoding a protein that is a member of the G protein-coupled receptor (GPCR) family, essential in the detection and perception of odors. Located in the olfactory epithelium, receptors like Olfr859 play a pivotal role in converting chemical signals from odorants into electrical signals, which are then interpreted by the brain as distinct smells. The activation of Olfr859 involves the direct binding of specific odorant molecules, crucial for triggering a conformational change in the receptor. This change subsequently activates the associated G protein, leading to a cascade of intracellular signaling events. Typically, this process includes the activation of adenylate cyclase, converting ATP to cyclic AMP (cAMP). Elevated levels of cAMP activate protein kinase A (PKA), which phosphorylates various cellular targets, culminating in the opening of ion channels. This ion influx generates an electrical signal that is transmitted to the brain and perceived as a specific odor.
The specificity of Olfr859's activation is determined by the structural compatibility between the receptor and the odorant molecule. The chemicals listed in the table have been selected for their potential to fit into the active site of Olfr859, thereby directly activating the receptor through a lock-and-key mechanism. This direct interaction is essential for the functional activation of Olfr859, initiating the olfactory signaling cascade. The ability of these chemicals to activate Olfr859 emphasizes the diversity and complexity of the olfactory system, highlighting the intricate relationship between the chemical structure of odorants and the activation of specific olfactory receptors. The direct activation of Olfr859 by these chemicals illustrates the receptor's selectivity and its crucial role in the nuanced process of olfaction, contributing to the diverse array of smells that humans are able to perceive.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate activates Olfr859 by directly binding to its ligand-binding domain, leading to a conformational change in the protein and initiating the olfactory signaling pathway. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate, known for its banana-like odor, can activate Olfr859 by fitting into the receptor binding site, triggering a signal transduction cascade in the olfactory pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, can activate Olfr859 through direct interaction with the receptor site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole, a monoterpene, activates Olfr859 through direct binding. Its interaction with the olfactory receptor triggers intracellular events, leading to the perception of its characteristic eucalyptus smell. | ||||||
Dipentene | 138-86-3 | sc-252747 | 4 L | $120.00 | ||
Dipentene, a cyclic terpene, activates Olfr859 by directly binding to the receptor's ligand-binding domain, causing a conformational change and initiating the olfactory signaling cascade. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr859 by fitting into its binding pocket, leading to a change in the receptor's conformation and triggering the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr859 through direct binding. Its molecular structure allows effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, a phenolic aldehyde, activates Olfr859 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to olfactory signal activation. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr859 through direct binding, causing a conformational change in the receptor and initiating a specific signaling pathway for olfactory receptors. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, an aldehyde with a grassy odor, activates Olfr859 by directly interacting with the receptor, effectively binding to initiate the olfactory signaling cascade. | ||||||