Olfr740 Activators
Olfr740 is an olfactory receptor protein that plays a critical role in the perception of odors. Like other olfactory receptors, Olfr740 is a member of the G protein-coupled receptor (GPCR) family. These receptors are integral membrane proteins that detect external chemical stimuli and translate these signals into cellular responses. Olfr740, specifically, is involved in detecting a range of odorant molecules, each with unique chemical structures. The activation of Olfr740, similar to other olfactory receptors, involves the direct binding of specific odorant molecules. This binding leads to a conformational change in the receptor, which is the primary mechanism through which these receptors are activated. Upon binding of an odorant molecule to Olfr740, there is a shift in the receptor's structure, enabling it to interact with and activate a G protein. This G protein activation sets off a cascade of intracellular signaling events. Typically, this involves the activation of adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). Increased levels of cAMP in the cell lead to the activation of protein kinase A (PKA), which then phosphorylates various cellular targets, resulting in the generation of a nerve impulse that is transmitted to the brain, where it is interpreted as a specific smell.
The chemicals listed in the table are selected based on their potential ability to fit into the active site of Olfr740, thereby directly activating the receptor through a lock-and-key mechanism. This direct interaction with the receptor is critical for the functional activation of Olfr740, leading to the initiation of the olfactory signaling cascade. This cascade is essential for the perception of odors and is a fundamental process in the olfactory system. The specificity of this interaction underscores the diverse nature of odorant molecules and their unique ability to activate specific olfactory receptors like Olfr740, contributing to the rich tapestry of smells that we are able to perceive.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate can activate Olfr740 by binding directly to its olfactory receptor site. This ester, known for its fruity odor, likely fits the receptor's active site, triggering the activation of the receptor and initiating the olfactory signaling pathway. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
trans-Anethole, a component of anise and fennel, activates Olfr740 through direct interaction with the receptor. This interaction results in a conformational change in the receptor, leading to the activation of olfactory signal transduction. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde, the compound that gives cinnamon its flavor, activates Olfr740 by binding to the receptor's active site. Its interaction induces a conformational change, leading to the activation of olfactory signaling mechanisms. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a key component of clove oil, activates Olfr740 through direct binding to the receptor. This interaction causes a change in the receptor structure, triggering a cascade of intracellular signaling events. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a terpene alcohol found in rose oil, activates Olfr740 by interacting directly with the receptor. This interaction leads to a conformational change in the receptor, initiating the olfactory signaling pathway. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $29.00 | ||
Isovaleric acid, known for its strong odor, activates Olfr740 by binding to the receptor. This direct interaction causes a conformational change in the receptor, leading to the initiation of olfactory signal transduction. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a citrus-scented terpene, activates Olfr740 by directly interacting with its ligand-binding domain, causing a structural change and initiating the olfactory signaling cascade. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol, a compound found in mint oils, activates Olfr740 by binding to the receptor's active site. This binding triggers a conformational change in the receptor, leading to the activation of the olfactory signal transduction pathway. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal, an aldehyde with a citrus-like odor, activates Olfr740 by directly binding to the receptor, leading to a conformational change and subsequent activation of olfactory signaling mechanisms. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol, a compound with a floral scent, activates Olfr740 by directly interacting with the receptor, causing a conformational change and initiating the olfactory signal transduction pathway. | ||||||