Olfr592 Activators
Olfr592, as a member of the olfactory receptor family, plays a pivotal role in the detection and discrimination of various odors. These receptors, which belong to the G-protein-coupled receptor (GPCR) superfamily, are specifically designed to respond to a wide array of volatile chemical compounds. The functional activation of Olfr592 is a critical step in the process of olfaction, allowing organisms to perceive and interpret the complex world of scents. The mechanism of activation of Olfr592 is characterized by the direct binding of specific chemical ligands to the receptor. This binding is highly selective, ensuring that Olfr592 is activated by particular odorant molecules. Upon ligand binding, Olfr592 undergoes a conformational change, which is the primary event initiating its activation. This structural alteration in the receptor leads to the activation of its associated G-protein, typically G_olf in olfactory neurons. The activated G-protein undergoes a change from GDP to GTP on the G_α subunit, which then dissociates from the G_βγ dimer. This dissociation leads to the activation of adenylate cyclase III, catalyzing the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels results in the opening of cyclic nucleotide-gated ion channels, permitting the influx of calcium and sodium ions into the cell. This ion influx generates an electrical signal that is transmitted to the brain, culminating in the perception of a distinct odor.
The precise and selective activation of Olfr592 by specific chemical ligands underlines the sophistication of the olfactory system. This specificity is crucial for the accurate detection and differentiation of a vast range of odors, highlighting the intricate interplay between chemical compounds and biological receptors. The process of olfactory perception, exemplified by the activation of Olfr592, showcases the complex and finely-tuned mechanisms that underlie sensory systems. The functional activation of Olfr592 by distinct odorant molecules not only emphasizes the receptor's role in olfactory perception but also illustrates the broader principles of receptor-ligand interactions in biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr592 by directly binding to its specific odorant-binding site. This binding induces a conformational change in the receptor, leading to the activation of G-protein signaling cascades that are crucial for olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool interacts with Olfr592 through direct binding to its ligand-binding domain. This interaction triggers a conformational change in the receptor, activating the associated G-protein signaling pathways integral for the olfactory perception process. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol activates Olfr592 by directly binding to its odorant-binding site, inducing a structural change necessary for receptor activation. This activation initiates G-protein coupled signaling mechanisms, essential for olfactory signal processing. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate activates Olfr592 through direct interaction with its odorant receptor site. This interaction induces a conformational shift in the receptor, triggering the activation of G-protein coupled signaling pathways crucial for olfactory perception. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate binds directly to Olfr592, resulting in receptor activation. This interaction leads to the initiation of G-protein mediated signal transduction pathways, playing a critical role in the sensory response of olfaction. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $40.00 | ||
Geranyl acetate interacts with Olfr592 at its odorant-binding site, activating the receptor. This activation triggers a series of G-protein mediated signaling events, fundamental for the function of olfactory receptors in scent detection. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate activates Olfr592 by binding directly to its specific ligand-binding domain, causing a conformational change and triggering the activation of associated G-protein signaling pathways crucial for olfactory processing. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde, by directly interacting with Olfr592, activates the receptor. This activation is key to initiating intracellular signaling cascades mediated by G-proteins, integral to the olfactory response mechanism. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamic Aldehyde binds to Olfr592, causing receptor activation through a structural change. This activation facilitates the propagation of olfactory signaling pathways, essential for the perception of specific scents. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol activates Olfr592 through direct ligand-receptor interaction. This binding induces a conformational alteration essential for receptor activation, leading to the initiation of G-protein signaling pathways involved in olfactory signal processing. | ||||||