Olfr438 Inhibitors
Olfr438, a member of the olfactory receptor family, serves a pivotal role in initiating the neuronal response responsible for the perception of smell through the interaction with odorant molecules in the nose. As a G-protein-coupled receptor (GPCR) with a distinctive 7-transmembrane domain structure, Olfr438 is integral to the recognition and G protein-mediated transduction of odorant signals, contributing to the vast complexity of the olfactory receptor gene family, the largest in the genome.
The inhibition of Olfr438 involves a diverse array of mechanisms, including both direct and indirect inhibitors, offering a nuanced approach to disrupting its function in odorant signal transduction. Direct inhibitors such as Picrotoxin and Gallein target the receptor's structure, hindering its ability to transduce signals effectively. Indirect inhibitors like Rimonabant and Thioridazine modulate various cellular pathways, such as cyclic nucleotide signaling, intracellular calcium levels, and downstream kinase activities, all crucial for the proper functioning of Olfr438. These inhibitors collectively provide valuable insights into the intricate molecular processes underlying olfactory perception. Experimental validation of these mechanisms is crucial for advancing our understanding of Olfr438 and its potential applications in olfactory research.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Direct inhibitor binding to Olfr438, disrupting its 7-transmembrane domain structure and impeding G protein-mediated transduction of odorant signals. This compound hinders the initiation of neuronal responses crucial for the perception of smell. | ||||||
Rimonabant | 168273-06-1 | sc-205491 sc-205491A | 5 mg 10 mg | $73.00 $163.00 | 15 | |
Modulator of olfactory-related intracellular cAMP levels, indirectly influencing Olfr438 function by altering cyclic nucleotide signaling and intracellular processes essential for the transduction of odorant signals. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Inhibitor affecting olfactory receptor desensitization mechanisms, indirectly influencing Olfr438 by prolonging its responsiveness to odorant stimuli and affecting the overall perception of smell. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Inhibitor targeting specific G protein subtypes involved in Olfr438 signaling, disrupting the downstream events crucial for the proper transduction of odorant signals and subsequent neuronal responses. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Modulator of intracellular calcium levels, indirectly inhibiting Olfr438 by influencing calcium-dependent events in the olfactory signaling cascade, essential for the proper transduction of odorant signals. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Inhibitor of the cAMP-dependent protein kinase (PKA) pathway associated with Olfr438, affecting the phosphorylation events crucial for G protein-mediated transduction of odorant signals. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
Modulator of intracellular calcium levels, indirectly influencing Olfr438 by disrupting calcium-dependent events in the olfactory signaling cascade, essential for the proper transduction of odorant signals. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $104.00 | 20 | |
Inhibitor targeting specific ion channels associated with Olfr438, disrupting the proper ion flux crucial for efficient G protein-mediated transduction of odorant signals. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Inhibitor affecting olfactory receptor recycling pathways, indirectly inhibiting Olfr438 function by interfering with the proper membrane localization and turnover of the receptor protein. | ||||||
KT5823 | 126643-37-6 | sc-3534 sc-3534A sc-3534B | 100 µg 1 mg 5 mg | $182.00 $1228.00 $4895.00 | 21 | |
Inhibitor of a specific downstream kinase in the Olfr438 signaling cascade, disrupting the phosphorylation events essential for efficient G protein-mediated transduction of odorant signals. | ||||||