Olfr419 Inhibitors
The Olfr419 olfactory receptor, a prominent member of the extensive G-protein-coupled receptor (GPCR) family, orchestrates the initiation of neuronal responses crucial for perceiving smells. With its 7-transmembrane domain structure, Olfr419 plays a pivotal role in the recognition and G protein-mediated transduction of odorant signals. As a key component of the largest olfactory receptor gene family, Olfr419 contributes significantly to the complex landscape of olfactory perception.
The inhibition of Olfr419 involves a nuanced interplay of direct and indirect mechanisms. Direct inhibitors, such as eucalyptol, 2-methylbutanal, butyric acid, isoamyl acetate, hexanoic acid, and isovaleric acid, act by binding to Olfr419 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibitors, including citral, nerol, thymol, eugenol, methyl salicylate, and geranyl acetate, modulate the cyclic nucleotide signaling pathway associated with Olfr419. Their influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. This diverse array of inhibitors provides a comprehensive approach to disrupting Olfr419's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirming the efficacy of these inhibitors in practice and further unraveling the intricacies of olfactory signal transduction mediated by Olfr419.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
1,8-Cineole serves as a direct inhibitor by binding to Olfr419 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyric acid serves as a direct inhibitor by binding to Olfr419 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate functions as a direct inhibitor by binding to Olfr419 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $28.00 | ||
Isovaleric acid functions as a direct inhibitor by binding to Olfr419 and disrupting its 7-transmembrane domain structure. This interference impedes the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $40.00 | ||
Geranyl acetate acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway associated with Olfr419. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||