Olfr399 Inhibitors
The Olfr399 olfactory receptor, belonging to the G-protein-coupled receptor (GPCR) family, is instrumental in the intricate process of odor perception. As a member of the olfactory receptor gene family characterized by single coding-exon genes and a 7-transmembrane domain structure, Olfr399 plays a pivotal role in recognizing and transducing odorant signals through G protein-mediated pathways. The olfactory receptor gene family, encompassing Olfr399, stands as the largest in the genome, underscoring the significance of these receptors in the sensory function of organisms.
Inhibiting Olfr399 involves a multifaceted approach, employing both direct and indirect mechanisms. Direct inhibition disrupts the receptor's function by binding to it and interfering with the 7-transmembrane domain structure, hindering its ability to transduce odorant signals effectively. Indirect inhibition, on the other hand, targets associated signaling pathways such as cAMP, TRP channels, and GABAergic transmission. These indirect inhibitors modulate the G protein-mediated transduction of signals, providing an additional layer of inhibition for olfactory perception. The diverse array of inhibitors collectively reflects a comprehensive strategy to disrupt Olfr399's role in odor recognition, offering potential avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirm the efficacy of these inhibitors in practice and further unravel the intricacies of olfactory signal transduction mediated by Olfr399.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral functions as a direct inhibitor by interfering with the binding of odorant molecules to Olfr399. Its inhibitory action disrupts the initiation of the neuronal response, thus impeding the perception of smell mediated by the olfactory receptor. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate functions as a direct inhibitor by interfering with the binding of odorant molecules to Olfr399. Its inhibitory action disrupts the initiation of the neuronal response, thus impeding the perception of smell mediated by the olfactory receptor. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin acts as an indirect inhibitor by targeting TRPV1 channels linked to Olfr399 signaling. Through modulation of TRPV1, capsaicin influences G protein-mediated transduction, leading to the indirect inhibition of the olfactory receptor and the perception of smell. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin acts as an indirect inhibitor by influencing the GABAergic signaling pathway associated with Olfr399. Its modulation of GABAergic transmission disrupts the downstream processes linked to olfactory signal transduction, providing an indirect inhibition of the olfactory receptor. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol serves as a direct inhibitor by binding to Olfr399 and disrupting the 7-transmembrane domain structure. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-pinene acts as an indirect inhibitor by modulating the cyclic nucleotide signaling pathway linked to Olfr399. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
1-Octen-3-ol | 3391-86-4 | sc-237604 | 25 g | $50.00 | ||
1-Octen-3-ol functions as a direct inhibitor by disrupting the 7-transmembrane domain structure of Olfr399. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||