Olfr344 Inhibitors
The functional inhibition of Olfr344 can be achieved through various chemicals that interact with its signaling pathways and modulatory systems. Dopamine receptor antagonists and agonists are known to influence olfactory transduction, and selective targeting of these receptors can result in the indirect inhibition of Olfr344. Compounds that modulate these receptors may alter the signaling cascade that leads to the activation of olfactory receptors, thereby affecting the functional activity of Olfr344. Additionally, chemicals that interact with the renin-angiotensin system, such as ACE inhibitors, can indirectly affect the metabolic processes related to olfactory function and thus Olfr344 signaling. Metal ions like zinc and copper can bind to olfactory receptors and induce conformational changes or competitive inhibition, which in turn can interfere with the proper functioning of Olfr344. These interactions showcase how targeting the broader olfactory reception mechanisms can indirectly lead to reduced activity of specific receptors such as Olfr344.
Further, the inhibition of protein synthesis in olfactory neurons, as seen with certain translational inhibitors, can lead to a decrease in the overall levels of olfactory receptors, including Olfr344. Disruption of cellular transport mechanisms by chemicals that alkalize intracellular compartments can also prevent the proper trafficking of olfactory receptors to the cell surface, thereby inhibiting Olfr344 activity. The modulation of other neurotransmitter systems, such as the cholinergic system, can result in changes in the neural processing of olfactory information and thus indirectly inhibit Olfr344. Exposure to heavy metals and other toxic substances has been shown to cause damage to the olfactory epithelium, which could lead to a reduction in Olfr344 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SCH 23390 | 125941-87-9 | sc-200408 sc-200408A | 5 mg 25 mg | $175.00 $719.00 | 2 | |
A selective antagonist for the dopamine D1 receptor which, when inhibited, leads to downstream effects including the modulation of olfactory transduction processes, thereby indirectly inhibiting Olfr344 activity. | ||||||
(−)-Quinpirole hydrochloride | 85798-08-9 | sc-253339 | 10 mg | $138.00 | 1 | |
A dopamine D2 receptor agonist that negatively modulates the D2-mediated signaling pathways, which are known to interact with olfactory receptor function, potentially reducing Olfr344 activity. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $48.00 $89.00 | 21 | |
An angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure and consequently alters renal function, which can affect the metabolic clearance of molecules, indirectly influencing Olfr344 signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Acts as an allosteric modulator of olfactory receptors and can alter the receptor conformation, thereby potentially inhibiting Olfr344 function due to structural changes. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Competitively binds to and interferes with the metal ion binding sites on olfactory receptors, which could hinder Olfr344 signaling by altering receptor conformation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits protein synthesis in eukaryotic organisms by interfering with the translocation step in protein synthesis, thus indirectly reducing the levels of olfactory receptor proteins including Olfr344. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Can alkalize cellular vesicles and affect vesicular trafficking. This may indirectly inhibit Olfr344 by disrupting the transport of the receptor to the cell surface. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium is known to affect the olfactory system by damaging olfactory epithelium and could indirectly inhibit Olfr344 through receptor cell damage and loss of receptor function. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Arsenic compounds can disrupt cellular signaling pathways and stress responses, potentially leading to a decrease in the functional expression of olfactory receptors like Olfr344. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
An agonist at TRPM8 receptors, which are expressed in some olfactory sensory neurons. Stimulation of these receptors can cause a change in the perception of odors, indirectly affecting Olfr344 functionality through sensory interaction. | ||||||