Olfr1105 Activators
Olfr1105 Activators encompass a diverse range of chemical compounds that indirectly augment the functional activity of Olfr1105 through various signaling pathways. Icilin and Menthol, both TRPM8 channel agonists, play a pivotal role in this enhancement. The activation of TRPM8 by these compounds leads to an amplified olfactory signaling cascade, essential for the proper functioning of Olfr1105 in olfactory neurons. In parallel, the beta-adrenergic agonist Isoproterenol and the adenylyl cyclase activator Forskolin, by elevating intracellular cAMP levels, indirectly boost Olfr1105's role in olfactory signal transduction. This is achieved through the activation of protein kinase A (PKA), which modulates various signaling pathways intersecting with olfactory receptor functioning. Furthermore, Zinc sulfate contributes to this enhancement by potentially altering the conformation of Olfr1105, thereby increasing its sensitivity to odorants. Phosphodiesterase inhibitors like IBMX, Theophylline, and Caffeine, work by preventing cAMP breakdown, thereby sustaining elevated cAMP levels and indirectly strengthening Olfr1105's signal transduction role.
The amplification of Olfr1105 activity is further influenced by compounds that modulate various other cellular pathways. Pilocarpine and Donepezil, impacting the cholinergic system, along with Nicotine, which activates nicotinic acetylcholine receptors, potentially enhance Olfr1105 function through their influence on olfactory signal processing. Capsaicin, a TRPV1 agonist, introduces an interesting dimension to Olfr1105 activation, as it may cross-activate sensory pathways that influence olfactory receptor functions, including that of Olfr1105. Collectively, these Olfr1105 Activators, through their targeted effects on cellular signaling and receptor modulation, facilitate the enhancement of Olfr1105 mediated functions, crucial for the complex process of olfaction. These interactions illustrate a sophisticated network of biochemical pathways converging to modulate the activity of a singular olfactory receptor, underscoring the intricate nature of sensory perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $89.00 $252.00 | 9 | |
Icilin, a synthetic super-agonist of the transient receptor potential melastatin 8 (TRPM8) channel, indirectly promotes Olfr1105 activity. TRPM8 activation leads to an enhanced olfactory signaling cascade, crucial for Olfr1105 in olfactory neurons. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, increases cAMP levels, which activate protein kinase A (PKA). PKA modulates signaling pathways intersecting with olfactory transduction, indirectly enhancing Olfr1105's functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels and thereby activating PKA. This elevation in cAMP enhances Olfr1105 functionality by promoting its role in olfactory signal transduction. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate modulates olfactory receptor function. It binds to receptors, including Olfr1105, potentially altering its conformation and enhancing its sensitivity to odorants. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a non-selective inhibitor of phosphodiesterases, increases cAMP levels by preventing its breakdown. Elevated cAMP indirectly enhances Olfr1105 activity by strengthening the olfactory signal transduction. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline, another phosphodiesterase inhibitor, raises intracellular cAMP levels, thus indirectly enhancing Olfr1105 function by amplifying olfactory signaling pathways. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Pilocarpine, a muscarinic acetylcholine receptor agonist, indirectly affects olfactory receptor activity, including Olfr1105, by modulating the cholinergic system, which can influence olfactory signal processing. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, an agonist of the transient receptor potential vanilloid 1 (TRPV1), may influence olfactory receptor functions like Olfr1105 through cross-activation of sensory pathways involved in olfaction. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $40.00 | 2 | |
Menthol, a TRPM8 agonist like Icilin, indirectly enhances Olfr1105 activity by stimulating the TRPM8 channel, which plays a role in olfactory signaling. | ||||||
Donepezil | 120014-06-4 | sc-279006 | 10 mg | $73.00 | 3 | |
Donepezil, an acetylcholinesterase inhibitor, increases acetylcholine levels, thereby potentially enhancing olfactory receptor functions including Olfr1105 through cholinergic system modulation. | ||||||