Nup35 Activators

Nup35, also known as nucleoporin 35 or Nup53, is a protein that is a key component of the nuclear pore complex (NPC), which regulates the transport of molecules between the nucleus and the cytoplasm in eukaryotic cells. Nup35 is a non-fibrous, scaffold nucleoporin, which means it contributes to the structural core of the NPC and is involved in anchoring other nucleoporins that form the transport channel.

This protein is involved in several fundamental cellular processes, including nucleocytoplasmic trafficking, gene expression regulation, and the cell cycle. Nup35 interacts with various nuclear transport receptors and plays a role in the bidirectional transport of RNA and proteins across the nuclear envelope. It is also implicated in the assembly and disassembly of the NPC during cell division, ensuring that genetic material and other critical cellular components are accurately shared between daughter cells.Mutations or dysregulation of Nup35 can lead to disruptions in nuclear transport, which may contribute to the development of diseases, including cancer and viral infections, where the integrity of the nuclear transport system is often compromised.