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NUDT17 Inhibitors

Nucleoside diphosphate-linked moiety X motif 17 (NUDT17) Inhibitors consist of a diverse array of chemical compounds that inhibit the functional activity of NUDT17 by targeting various aspects of nucleotide metabolism and availability. Compounds such as Hydroxyurea, Methotrexate, Mycophenolic acid, and Fluorouracil exert their inhibitory effects by disrupting the synthesis of ribonucleotides and deoxyribonucleotides, thereby potentially limiting the substrates that NUDT17 requires to function. Allopurinol and 6-Thioguanine, by interfering with purine catabolism and acting as purine antimetabolites respectively, may diminish NUDT17's activity by altering the balance of nucleotides within the cell. This shift in nucleotide pools could reduce the availability of specific substrates that NUDT17 acts upon, thereby indirectly decreasing its activity. Similarly, Azathioprine, which is metabolized into 6-mercaptopurine, inhibits purine synthesis and could lead to a decrease in NUDT17 activity by limiting necessary substrates. Ribavirin, 3′-Azido-3′-deoxythymidine, and Tenofovir, as nucleotide analogues, may contribute to the inhibition of NUDT17 by interfering with nucleotide synthesis and metabolism. Adenosine, by modulating adenosine receptors, can lead to decreased cAMP levels, which in turn could reduce the activity of protein kinases such as PKA that might be responsible for modifying substrates or regulatory proteins relevant to NUDT17's function. The inhibition of ribonucleotide reductase by Hydroxyurea and 2-Chloro-2′-deoxyadenosine affects the deoxyribonucleotide pools, which are crucial for DNA synthesis and repair, pathways that NUDT17 may be involved in. These inhibitors, through their targeted effects on nucleotide synthesis, metabolism, and signaling pathways, collectively contribute to the indirect inhibition of NUDT17 by modulating the chemical environment that influences its functional activity. The chemical-mediated alteration in substrate availability and modification processes without directly targeting NUDT17's catalytic activity underscores the intricacy of cellular regulation and the potential for indirect inhibition through the manipulation of metabolic pathways.

Items 1 to 10 of 12 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Adenosine	58-61-7	sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F	1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg	$33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00	1	(0)
Adenosine interacts with adenosine receptors, which can inhibit adenylate cyclase activity, decreasing cAMP levels. This reduction in cAMP can decrease PKA activity, which may indirectly reduce NUDT17 activity by affecting protein modification processes that NUDT17 may regulate.
Hydroxyurea	127-07-1	sc-29061 sc-29061A	5 g 25 g	$76.00 $255.00	18	(1)
Hydroxyurea inhibits ribonucleotide reductase, leading to a decrease in deoxyribonucleotide pools, which could indirectly affect NUDT17 function by altering the substrate availability that NUDT17 might act upon.
Allopurinol	315-30-0	sc-207272	25 g	$128.00		(0)
Allopurinol inhibits xanthine oxidase, disrupting purine catabolism and potentially altering the cellular balance of nucleotides and their derivatives, thereby potentially diminishing NUDT17's activity by affecting its substrate spectrum.
Methotrexate	59-05-2	sc-3507 sc-3507A	100 mg 500 mg	$92.00 $209.00	33	(5)
Methotrexate inhibits dihydrofolate reductase, leading to reduced purine synthesis. This could indirectly affect NUDT17 by altering the levels of nucleotides and potentially diminishing its activity through substrate limitation.
Mycophenolic acid	24280-93-1	sc-200110 sc-200110A	100 mg 500 mg	$68.00 $261.00	8	(1)
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, affecting purine synthesis. This could lead to an indirect decrease in NUDT17 activity by modifying the levels of substrates on which NUDT17 acts.
Ribavirin	36791-04-5	sc-203238 sc-203238A sc-203238B	10 mg 100 mg 5 g	$62.00 $108.00 $210.00	1	(1)
Ribavirin is a nucleoside analogue that can interfere with nucleotide synthesis and metabolism. The perturbation of nucleotide pools could indirectly lead to diminished NUDT17 activity by impacting the availability of its substrates.
Fluorouracil	51-21-8	sc-29060 sc-29060A	1 g 5 g	$36.00 $149.00	11	(1)
Fluorouracil is a pyrimidine analogue that disrupts nucleotide metabolism. By interfering with pyrimidine metabolism, the availability of substrates for NUDT17 could be altered, leading to a decrease in its functional activity.
Azathioprine	446-86-6	sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C	500 mg 1 g 2 g 5 g 10 g	$199.00 $173.00 $342.00 $495.00 $690.00	1	(1)
Azathioprine is metabolized into 6-mercaptopurine, which inhibits purine synthesis. This could lead to a decrease in NUDT17 activity by affecting the concentration of substrates necessary for its function.
6-Thioguanine	154-42-7	sc-205587 sc-205587A	250 mg 500 mg	$41.00 $53.00	3	(1)
6-Thioguanine is an analogue of guanine and acts as a purine antimetabolite, which could lead to diminished NUDT17 activity by altering the pool of nucleotides and possibly affecting the availability of substrates for NUDT17.
3′-Azido-3′-deoxythymidine	30516-87-1	sc-203319	10 mg	$60.00	2	(1)
3′-Azido-3′-deoxythymidine is a nucleoside reverse transcriptase inhibitor and can affect cellular nucleotide levels. This may lead to decreased NUDT17 activity by affecting the balance of nucleotides and the availability of NUDT17's substrates.

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