Date published: 2025-12-8

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NMBR Inhibitors

Neuromedin B Receptor (NMBR) inhibitors encompass a variety of compounds primarily aimed at modulating the signaling pathways of this G-protein-coupled receptor. NMBR plays a pivotal role in diverse physiological processes, and its inhibitors are crucial for understanding and potentially manipulating these processes. Direct inhibitors like PD168368, BIM-23127, and JMV 1843 exhibit high affinity and specificity to NMBR, blocking the receptor's ability to respond to its natural ligand, neuromedin B. These inhibitors are valuable tools in researching the physiological and pathophysiological roles of NMBR in systems ranging from smooth muscle contraction to the regulation of energy balance. Indirect inhibitors of NMBR, such as RC-3095 and L-733,060, target related receptors or pathways, thereby modulating NMBR functions. For instance, antagonists of the GRP receptor or tachykinin receptors can influence NMBR activity due to the interconnected nature of neuropeptide signaling. This indirect approach offers insights into the broader network of G-protein-coupled receptor signaling and its impact on physiological processes. Moreover, the use of dual antagonists like PD176252, which targets both NMBR and GRPR, highlights the complex interplay between different neuromedin receptors.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PD 168368

204066-82-0sc-204166
sc-204166A
1 mg
10 mg
$149.00
$312.00
3
(1)

PD 168368 is a selective compound that acts as a potent inhibitor of specific protein interactions, influencing cellular signaling cascades. Its unique structure allows for precise binding to target proteins, modulating their activity and altering downstream effects. The compound exhibits distinct reaction kinetics, characterized by rapid association and slower dissociation rates, which enhances its efficacy in disrupting molecular pathways. This specificity underscores its role in elucidating complex biochemical networks.

PD 176252

204067-01-6sc-204171A
sc-204171
1 mg
5 mg
$100.00
$295.00
(1)

PD 176252 is a highly reactive acid halide known for its ability to form stable covalent bonds with nucleophiles, facilitating unique synthetic pathways. Its electrophilic nature promotes rapid acylation reactions, leading to the formation of diverse derivatives. The compound's distinct steric and electronic properties influence its reactivity profile, allowing for selective modifications in complex organic frameworks. This behavior is pivotal in advancing synthetic methodologies and exploring novel chemical transformations.

SB 222200

174635-69-9sc-224282
sc-224282A
10 mg
50 mg
$205.00
$800.00
1
(0)

SB-222200 selectively antagonizes NMBR, inhibiting its signaling and associated physiological effects.

Neuromedin

81608-30-2sc-396716
1 mg
$169.00
(0)

Neuromedin is a gastrin-releasing peptide fragment that acts as a competitive antagonist for NMBR, inhibiting its signaling pathways.

MEN10376

135306-85-3sc-201172
1 mg
$111.00
1
(0)

MEN 10376 is a tachykinin receptor antagonist, which can indirectly influence NMBR activity through its effects on related neuropeptide systems.