Nkx-6.1 Inhibitors
Nkx-6.1 inhibitors represent a versatile category of chemicals with the capacity to finely tune the expression and function of Nkx-6.1 by engaging specific and intricate cellular signaling pathways. These inhibitors operate by strategically targeting key components within various signaling cascades, thereby indirectly influencing the activity of Nkx-6.1. One exemplar within this class is Staurosporine, recognized as a broad-spectrum kinase inhibitor. Staurosporine modulates Nkx-6.1 by intricately impacting the Akt pathway. Through the disruption of Akt signaling, the compound induces a shift in the cellular context, thereby altering the expression and function of Nkx-6.1 within the realm of immune regulation processes.
Moreover, inhibitors like U0126 and Trametinib, specifically designed to target MEK1/2 within the MAPK/ERK pathway, contribute to the indirect modulation of Nkx-6.1. By impeding MEK, these inhibitors instigate a cascade of events that perturb downstream signaling dynamics. This, in turn, furnishes an indirect mechanism to regulate Nkx-6.1, influencing its expression and functional activity. The significance of this class of chemicals lies in its ability to unravel the intricate interplay between cellular signaling pathways and the regulatory mechanisms governing Nkx-6.1. The insights gained from studying these inhibitors provide a valuable foundation for researchers aiming to manipulate this transcription factor in the pursuit of potential applications within cellular and molecular studies. As researchers delve deeper into the complexities of these interactions, the prospect of finely controlling Nkx-6.1 opens avenues for advancements in understanding and potentially harnessing its role in diverse cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that directly inhibits multiple kinases involved in various signaling pathways. It can indirectly modulate Nkx-6.1 by affecting the Akt pathway. As an inhibitor of Akt, Staurosporine disrupts the downstream signaling events that influence Nkx-6.1 expression and function, providing an indirect means of inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. Its action on PI3K indirectly affects Nkx-6.1 by disrupting the signaling events downstream. Inhibition of the PI3K/Akt pathway alters the cellular context, influencing the expression and function of Nkx-6.1 in a downstream manner. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK, a component of the MAPK signaling pathway. Through its action on JNK, SP600125 indirectly modulates Nkx-6.1. The inhibition of JNK alters the signaling milieu, impacting downstream events that regulate Nkx-6.1 expression and function, providing an indirect avenue for inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, impacting the PI3K/Akt pathway. By directly inhibiting PI3K, Wortmannin disrupts the downstream signaling events, indirectly influencing Nkx-6.1. The alteration of the PI3K/Akt pathway dynamics can modulate the expression and function of Nkx-6.1 in a downstream manner, serving as an indirect inhibitor. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, a crucial component of the MAPK signaling pathway. Through its action on p38 MAPK, SB203580 indirectly modulates Nkx-6.1. Inhibition of p38 MAPK disrupts downstream signaling events, influencing Nkx-6.1 expression and function in a manner that provides an indirect avenue for inhibition. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib is a selective inhibitor of MEK1/2 in the MAPK/ERK pathway. By targeting MEK, Trametinib disrupts downstream signaling, indirectly impacting Nkx-6.1. Inhibition of MEK alters the signaling landscape, influencing the expression and function of Nkx-6.1 in a manner that provides an indirect means of inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1, an upstream kinase in the MAPK/ERK pathway. Its action on MEK1 indirectly modulates Nkx-6.1 by disrupting downstream signaling. Inhibition of MEK1 alters the signaling dynamics, influencing Nkx-6.1 expression and function in a downstream manner, providing an indirect avenue for inhibition. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
Doramapimod (BIRB 796) is a selective inhibitor of p38 MAPK, a component of the MAPK signaling pathway. Through its action on p38 MAPK, BIRB 796 indirectly modulates Nkx-6.1. Inhibition of p38 MAPK disrupts downstream signaling events, influencing Nkx-6.1 expression and function in a manner that provides an indirect avenue for inhibition. | ||||||
VX 702 | 745833-23-2 | sc-361400 | 10 mg | $132.00 | 1 | |
VX-702 is a selective inhibitor of p38 MAPK, a crucial component of the MAPK signaling pathway. Through its action on p38 MAPK, VX-702 indirectly modulates Nkx-6.1. Inhibition of p38 MAPK disrupts downstream signaling events, influencing Nkx-6.1 expression and function in a manner that provides an indirect avenue for inhibition. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB202190 is a selective inhibitor of p38 MAPK, a component of the MAPK signaling pathway. Through its action on p38 MAPK, SB202190 indirectly modulates Nkx-6.1. Inhibition of p38 MAPK disrupts downstream signaling events, influencing Nkx-6.1 expression and function in a manner that provides an indirect avenue for inhibition. | ||||||