Nkx-3.2 Inhibitors
Nkx-3.2 inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of Nkx-3.2, a protein encoded by the NKX3-2 gene. Nkx-3.2, also known as NK3 homeobox 2, is a member of the NK family of homeobox genes, which play crucial roles in regulating developmental processes. This transcription factor is involved in the regulation of chondrogenesis, the process by which cartilage is formed from condensed mesenchyme tissue, and is essential for the proper development of the skeletal system. Nkx-3.2 functions by binding to specific DNA sequences and regulating the transcription of target genes that are involved in the differentiation and proliferation of chondrocytes, the cells responsible for cartilage formation.
Structurally, Nkx-3.2 inhibitors can vary widely, including small molecules, peptides, or larger biomolecules that are engineered to interact specifically with the DNA-binding domain or other critical regions of the Nkx-3.2 protein. These inhibitors typically function by preventing Nkx-3.2 from binding to its target DNA sequences, thereby blocking its ability to regulate gene transcription. By inhibiting Nkx-3.2, these compounds can disrupt the transcriptional networks controlled by this factor, leading to changes in the expression of genes involved in chondrocyte differentiation and cartilage formation. The study of Nkx-3.2 inhibitors is crucial for understanding the regulatory mechanisms underlying Nkx-3.2's role in gene expression and its impact on developmental processes. Research into these inhibitors provides valuable insights into the broader implications of transcription factor regulation in cellular biology, highlighting the importance of precise control of gene expression in maintaining cellular identity and function. By exploring the effects of Nkx-3.2 inhibition, scientists can gain a deeper understanding of the intricate networks of gene regulation and the role of transcription factors in orchestrating the complex processes of development and differentiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt signaling by blocking the Wnt/β-catenin pathway. NKX (NK homeobox) is involved in pancreatic development influenced by Wnt signaling, and inhibition of this pathway by IWP-2 can indirectly inhibit NKX (NK homeobox). | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT-61 inhibits Hedgehog (Hh) signaling by blocking the GLI transcription factors. NKX (NK homeobox) is part of the neural tube patterning influenced by Hh signaling, and GANT-61 can indirectly inhibit NKX (NK homeobox) by interfering with Hh pathway activity. | ||||||
SIS3 hydrochloride | 521984-48-5 | sc-253565 | 5 mg | $334.00 | 2 | |
SIS3 inhibits TGF-β/Smad3 signaling by blocking Smad3 phosphorylation. NKX (NK homeobox) is implicated in pancreatic development influenced by TGF-β signaling, and SIS3 can indirectly inhibit NKX (NK homeobox) by modulating the TGF-β/Smad3 pathway. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
DMH1 inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by DMH1 can indirectly inhibit NKX (NK homeobox), as NKX (NK homeobox) is implicated in neural development influenced by BMP signaling. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits Hedgehog (Hh) signaling by blocking Smoothened (SMO). NKX (NK homeobox) is part of neural tube patterning influenced by Hh signaling, and Cyclopamine can indirectly inhibit NKX (NK homeobox) by disrupting Hh pathway activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 inhibits TGF-β/Activin/Nodal signaling by blocking the type I receptors. NKX (NK homeobox) is implicated in pancreatic development influenced by TGF-β signaling, and SB431542 can indirectly inhibit NKX (NK homeobox) by interfering with the TGF-β/Activin/Nodal pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1-endo inhibits Wnt signaling by stabilizing Axin. NKX (NK homeobox) is involved in pancreatic development influenced by Wnt signaling, and IWR-1-endo can indirectly inhibit NKX (NK homeobox) by promoting the degradation of β-catenin and modulating Wnt pathway activity. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $182.00 $736.00 | 28 | |
Dorsomorphin inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by Dorsomorphin can indirectly inhibit NKX (NK homeobox), as NKX (NK homeobox) is implicated in neural development influenced by BMP signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
LY364947 inhibits TGF-β/Smad2/3 signaling by blocking the type I receptors. NKX (NK homeobox) is implicated in pancreatic development influenced by TGF-β signaling, and LY364947 can indirectly inhibit NKX (NK homeobox) by interfering with the TGF-β/Smad2/3 pathway. | ||||||