NF-M Inhibitors
The class of chemicals known as NF-M inhibitors consists of compounds that interfere with the microtubule dynamics crucial for NF-M (Neurofilament-M) function. Notable inhibitors in this class include Paclitaxel, Colchicine, and others, which act directly on microtubules, disrupting the transport of NF-M along the cytoskeleton. By targeting the cytoskeletal elements involved in NF-M function, these inhibitors offer valuable insights into potential strategies for modulating NF-M-dependent cellular processes. Understanding the intricate ways in which these chemicals impact NF-M contributes to advancing our knowledge of cytoskeletal dynamics and its implications for cellular function. Paclitaxel stabilizes microtubules by preventing depolymerization, thereby disrupting the normal dynamics of microtubules involved in NF-M transport. This interference affects the proper functioning of NF-M and has implications for cellular processes dependent on NF-M, such as axonal transport and structural integrity.
Colchicine, on the other hand, destabilizes microtubules by binding to tubulin, leading to their depolymerization. This destabilization interferes with the normal movement of NF-M along the cytoskeleton, impacting its role in maintaining neuronal structure and function. The direct action of these NF-M inhibitors on microtubules provides a targeted approach to modulating NF-M-dependent cellular processes. The disruption of NF-M function has broader implications for neurobiology, as neurofilaments play a crucial role in maintaining the structural integrity of neurons and facilitating intracellular transport. In summary, the class of NF-M inhibitors, including Taxol, Colchicine, and others, sheds light on the intricate relationship between microtubule dynamics and NF-M function. These inhibitors provide valuable tools for researchers studying the cytoskeleton and its role in cellular processes, particularly in the context of neurobiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol inhibits NF-M by targeting microtubule dynamics. As a taxane, paclitaxel stabilizes microtubules, leading to the impairment of NF-M transport along the cytoskeleton. This direct inhibition disrupts NF-M function, hindering its involvement in cellular processes dependent on proper cytoskeletal organization and dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine inhibits NF-M through interference with microtubule assembly. As a microtubule-depolymerizing agent, colchicine disrupts the formation of microtubule structures, directly affecting the binding and transport of NF-M along the cytoskeleton. This disruption leads to the inhibition of NF-M-dependent processes related to cytoskeletal organization and cellular transport. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine inhibits NF-M by disrupting microtubule dynamics. As a vinca alkaloid, vinblastine interferes with microtubule polymerization, leading to the impairment of NF-M transport along the cytoskeleton. This direct inhibition disrupts NF-M function, hindering its involvement in cellular processes dependent on proper cytoskeletal organization and dynamics. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B inhibits NF-M by stabilizing microtubules. As a microtubule-stabilizing agent, epothilone B enhances microtubule polymerization, leading to the impairment of NF-M transport along the cytoskeleton. This direct inhibition disrupts NF-M function, hindering its involvement in cellular processes dependent on proper cytoskeletal organization and dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole inhibits NF-M through interference with microtubule dynamics. As a microtubule-depolymerizing agent, nocodazole disrupts the formation of microtubule structures, directly affecting the binding and transport of NF-M along the cytoskeleton. This disruption leads to the inhibition of NF-M-dependent processes related to cytoskeletal organization and cellular transport. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin inhibits NF-M by targeting microtubule dynamics. As a microtubule-depolymerizing agent, griseofulvin disrupts the formation of microtubule structures, directly affecting the binding and transport of NF-M along the cytoskeleton. This disruption leads to the inhibition of NF-M-dependent processes related to cytoskeletal organization and cellular transport. | ||||||
Vinorelbine base | 71486-22-1 | sc-205885 sc-205885A sc-205885B sc-205885C sc-205885D | 1 mg 5 mg 25 mg 100 mg 1 g | $28.00 $79.00 $255.00 $775.00 $1938.00 | ||
Vinorelbine inhibits NF-M by disrupting microtubule dynamics. As a vinca alkaloid, vinorelbine interferes with microtubule polymerization, leading to the impairment of NF-M transport along the cytoskeleton. This direct inhibition disrupts NF-M function, hindering its involvement in cellular processes dependent on proper cytoskeletal organization and dynamics. | ||||||
Thiocolchicoside | 602-41-5 | sc-202839 sc-202839A | 1 mg 5 mg | $30.00 $120.00 | ||
Thiocolchicoside inhibits NF-M through interference with microtubule assembly. As a microtubule-depolymerizing agent, thiocolchicoside disrupts the formation of microtubule structures, directly affecting the binding and transport of NF-M along the cytoskeleton. This disruption leads to the inhibition of NF-M-dependent processes related to cytoskeletal organization and cellular transport. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Combretastatin A-4 inhibits NF-M by destabilizing microtubules. As a tubulin-binding agent, combretastatin A-4 promotes microtubule depolymerization, leading to the impairment of NF-M transport along the cytoskeleton. This direct inhibition disrupts NF-M function, hindering its involvement in cellular processes dependent on proper cytoskeletal organization and dynamics. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine inhibits NF-M by disrupting microtubule dynamics. As a microtubule-depolymerizing agent, estramustine disrupts the formation of microtubule structures, directly affecting the binding and transport of NF-M along the cytoskeleton. This disruption leads to the inhibition of NF-M-dependent processes related to cytoskeletal organization and cellular transport. | ||||||