NDUFB1 Activators
NDUFB1 activators are a group of chemical compounds that enhance the functional activity of the NADH:ubiquinone oxidoreductase subunit B1, a protein that plays a pivotal role in the electron transport chain of mitochondria, which is integral for ATP synthesis. Certain activators exert their effects by increasing intracellular levels of molecules that serve as second messengers, such as cAMP and cGMP, thereby stimulating protein kinases like PKA and PKG that can phosphorylate proteins within the electron transport chain, promoting enhanced activity. Other molecules work by binding to receptors or enzymes that influence metabolic pathways leading to increased mitochondrial biogenesis, which could result in a higher number of mitochondria with more active NDUFB1. Some compounds function by increasing the availability of essential cofactors and substrates required for mitochondrial function, such as electron carriers and fatty acids, thereby supporting the robust activity of NDUFB1 and facilitating efficient ATP production within the cell.
Furthermore, NDUFB1 activity can be indirectly influenced by activators that modulate the expression of genes involved in mitochondrial biogenesis and function. For instance, compounds that activate AMPK or PPARγ pathways lead to enhanced expression of proteins that support mitochondrial number and efficiency, creating an environment where NDUFB1's activity is upregulated. Other activators enhance the levels of sirtuins and NAD+, which are known to improve mitochondrial function, including the deacetylation and activation of proteins that interact with the electron transport chain.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Acts as an agonist for beta-adrenergic receptors, leading to an increase in cAMP production and activation of PKA. This activation may increase the phosphorylation of proteins involved in the electron transport chain, including NDUFB1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMP-activated protein kinase (AMPK), which can enhance mitochondrial biogenesis and may indirectly increase the functional activity of NDUFB1 within the newly formed mitochondria. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates sirtuin 1 (SIRT1), which can lead to deacetylation and activation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), potentially enhancing mitochondrial function and NDUFB1 activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Agonist of the peroxisome proliferator-activated receptor gamma (PPARγ), which influences mitochondrial biogenesis and could enhance the activity of proteins in the electron transport chain, including NDUFB1. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
A precursor of NAD+, which can enhance the sirtuin pathways and improve mitochondrial function, potentially leading to increased activity of NDUFB1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Activates AMPK, which promotes mitochondrial biogenesis and efficiency, potentially leading to elevated activity of mitochondrial proteins such as NDUFB1. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
Uncouples oxidative phosphorylation, which can lead to a compensatory increase in electron transport chain activity, indirectly enhancing the activity of NDUFB1. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Essential electron carrier in the electron transport chain, can enhance the efficiency of electron transfer and indirectly increase the activity of NDUFB1. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
Facilitates the transport of fatty acids into mitochondria for beta-oxidation, which can increase the demand for ATP production and indirectly enhance the activity of NDUFB1 within the electron transport chain. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Acts as a cofactor for mitochondrial enzymes, potentially improving mitochondrial function and indirectly enhancing the activity of NDUFB1. | ||||||