NAT-14 Activators
N-acetyltransferase 14 activators are compounds that increase the activity of NAT14 either by direct interaction with the enzyme, increasing the substrate availability, or modulating gene expression. The exact mechanisms by which these chemicals enhance NAT14 activity would depend on their interaction with either the enzyme itself or related cellular pathways.
For instance, compounds that increase the intracellular levels of acetyl-CoA could provide more substrate for NAT14, thereby enhancing its activity. Similarly, molecules that influence the epigenetic landscape of the cell, such as DNA methylation and histone acetylation status, could potentially increase the expression of the NAT14 gene, resulting in higher enzyme activity. Chemicals that modulate signaling pathways relevant to enzyme expression, such as those that increase cAMP levels like forskolin, could also result in increased NAT14 activity by upregulating its expression. On the other hand, compounds that alter the acetylation balance within the cell, such as histone deacetylase inhibitors or sirtuin activators, might indirectly affect NAT14 activity by creating a cellular environment that favors acetylation reactions.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA serves as a cofactor and an acetyl group donor for NATs. An increased concentration of acetyl-CoA can enhance NAT activity by providing more substrate for the enzymatic reaction. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
While primarily known as a methyl donor, this compound can serve as a donor for various groups and may influence acetyltransferase activity indirectly by altering methylation patterns that can affect gene expression, including that of NATs. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, can influence sirtuin activity which can affect the acetylation status of proteins, potentially altering NAT activity indirectly through cellular acetylation balance. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate sirtuins, a class of deacetylases. By altering the acetylation status within the cell, it may indirectly influence NAT activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways and has been shown to affect protein acetylation, which could potentially influence NAT activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can lead to altered gene expression and may upregulate NAT expression or activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects gene expression through its action on retinoic acid receptors and may upregulate enzymes like NATs. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can increase acetylation levels, potentially affecting NAT activity indirectly through changes in chromatin structure and gene expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as essential cofactors for many enzymes and may influence the folding and function of NATs. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG affects various signaling pathways and may influence NAT expression and activity through epigenetic modifications. | ||||||