NARFL Inhibitors
Chemical inhibitors of NARFL manipulate cellular pathways that are crucial for its function, particularly those involved in the assembly and maintenance of iron-sulfur clusters within the mitochondria. Cyclosporin A operates by inhibiting calcineurin, thereby indirectly affecting the cellular homeostasis and energy metabolism that NARFL requires to function efficiently. Oligomycin A exerts its inhibitory effect on mitochondrial ATP synthase, disrupting ATP production and thus the energy balance necessary for NARFL's role in biosynthetic pathways. Antimycin A and Rotenone target the mitochondrial electron transport chain, inhibiting complexes III and I, respectively. This diminishes the assembly of iron-sulfur clusters, which are vital for NARFL activity. Chloroquine disrupts iron homeostasis by altering endosomal pH, potentially hindering the iron-sulfur cluster assembly that NARFL facilitates.
Continuing with this theme, Deferoxamine chelates iron, directly impeding the availability of this essential metal for the iron-sulfur cluster assembly that NARFL is associated with. Zileuton's inhibition of 5-lipoxygenase alters leukotriene synthesis, which can indirectly modify the redox state within cells and thus affect the assembly of iron-sulfur clusters, leading to the inhibition of NARFL. Fenamiphos, an acetylcholinesterase inhibitor, may lead to oxidative stress, which in turn can impair the iron-sulfur cluster assembly machinery, thus inhibiting NARFL. The proteasome inhibitor Bortezomib disrupts protein homeostasis, which could lead to an indirect inhibition of NARFL by affecting its involvement in the iron-sulfur cluster assembly processes. Stattic, as a STAT3 inhibitor, changes gene expression profiles, potentially leading to a decrease in the cellular processes requiring NARFL. PD 98059 inhibits MEK in the MAPK pathway, potentially disrupting signaling pathways reliant on iron-sulfur cluster biogenesis, thus indirectly affecting NARFL. Lastly, Genistein, a tyrosine kinase inhibitor, could hinder signaling pathways that depend on the proper assembly of iron-sulfur clusters, which is necessary for the functional activity of NARFL in the cell.
SEE ALSO...
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin. Given NARFL's association with iron-sulfur cluster assembly, inhibition of calcineurin can disrupt cellular homeostasis and energy metabolism, thus indirectly inhibiting NARFL by impairing the environment it requires for proper function. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A inhibits mitochondrial ATP synthase. By disrupting ATP production, it affects cellular energy balance, which is crucial for the biosynthesis pathways, including those dependent on the proper function of NARFL. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A targets the mitochondrial electron transport chain by inhibiting complex III. This action can lead to a reduced production of iron-sulfur clusters, which are critical for NARFL function in mitochondrial processes. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor. By disrupting electron transport, it decreases the production of iron-sulfur clusters, thereby inhibiting the cellular processes that rely on NARFL function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises endosomal pH and is known for its antimalarial action. By altering the pH, Chloroquine can disrupt cellular iron homeostasis, potentially inhibiting NARFL's role in iron-sulfur cluster assembly. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
Deferoxamine is an iron chelator that can sequester iron, thereby potentially inhibiting the iron-sulfur cluster assembly process, which is essential for NARFL's function. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor and by inhibiting this enzyme, it can alter leukotriene synthesis. This pathway's alteration can indirectly affect cellular redox states and the iron-sulfur cluster assembly, thus inhibiting NARFL. | ||||||
Fenamiphos | 22224-92-6 | sc-239982 | 250 mg | $90.00 | ||
Fenamiphos is an organophosphate that inhibits acetylcholinesterase. Its inhibition can lead to altered neural signaling, oxidative stress, and indirectly impair iron-sulfur cluster assembly, inhibiting NARFL's activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By preventing protein degradation, it can lead to the accumulation of misfolded proteins, which may disrupt the iron-sulfur assembly machinery, indirectly inhibiting NARFL. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Stattic inhibits STAT3, a transcription factor involved in various signaling pathways. By inhibiting STAT3, Stattic can alter gene expression profiles, potentially leading to the inhibition of processes that require NARFL's function. | ||||||