N4bp2l1 Activators
Chemical activators of N4bp2l1 employ various cellular mechanisms to influence the activity of this protein. Bisindolylmaleimide I, for instance, is a selective inhibitor of protein kinase C (PKC). While its primary function is to inhibit PKC, this action can lead to the activation of N4bp2l1 due to complex compensatory cellular mechanisms that respond to the inhibition of PKC. Similarly, Forskolin raises cellular cAMP levels by directly stimulating adenylyl cyclase. Elevated cAMP then activates PKA, which can phosphorylate a range of cellular substrates. This cascade of phosphorylation events can involve N4bp2l1, leading to its activation. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent kinases like CaMK, which have the capacity to phosphorylate and thereby activate N4bp2l1.
Moreover, phorbol 12-myristate 13-acetate (PMA) activates PKC by functioning as a tumor promoter. The activation of PKC initiates phosphorylation cascades that can result in the activation of N4bp2l1. Okadaic Acid, as a potent inhibitor of protein phosphatases 1 and 2A, prevents dephosphorylation, thus maintaining proteins in a phosphorylated state, which can keep N4bp2l1 activated. Contrastingly, Anisomycin disrupts protein synthesis and activates stress-activated protein kinases (SAPKs), which can lead to the activation of N4bp2l1 as part of the cellular response to stress stimuli. Calyculin A, like Okadaic Acid, inhibits protein phosphatases, leading to sustained protein phosphorylation and possible activation of N4bp2l1. Thapsigargin inhibits SERCA, causing an increase in cytosolic calcium levels, which can lead to the activation of N4bp2l1 through calcium-dependent signaling pathways. Dibutyryl-cAMP, a cAMP analog, activates cAMP-dependent pathways, potentially leading to N4bp2l1 activation. Staurosporine, although a general protein kinase inhibitor, can alter the activity of various proteins indirectly leading to N4bp2l1 activation. Lastly, Piceatannol and H-89 inhibit specific kinases and PKA, respectively, which can result in the activation of alternative pathways that include N4bp2l1 activation as part of a broader cellular response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of protein kinase C (PKC). N4bp2l1, being a part of cellular processes regulated by PKC, can be activated through the PKC pathway. This chemical inhibits the PKC which can lead to the activation of downstream proteins like N4bp2l1 due to the compensatory cellular mechanisms. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, thereby increasing the cellular levels of cAMP. Elevated cAMP activates PKA, which in turn can phosphorylate various cellular substrates including proteins associated with N4bp2l1's pathway, leading to N4bp2l1 activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases such as CaMK, which are known to phosphorylate proteins and could thereby activate N4bp2l1 through phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and functions as a tumor promoter by activating PKC. The activation of PKC can initiate phosphorylation cascades that result in the activation of proteins in related pathways, including N4bp2l1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, which prevents the dephosphorylation of proteins. By inhibiting these phosphatases, it indirectly maintains the phosphorylation state of proteins, potentially leading to the sustained activation of N4bp2l1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that inhibits peptide elongation during protein synthesis and also activates stress-activated protein kinases (SAPKs). Activation of SAPKs can lead to the activation of N4bp2l1 as part of the cellular response to stress. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, similar to okadaic acid. By inhibiting dephosphorylation, Calyculin A can cause the activation of several proteins, including N4bp2l1, by maintaining their phosphorylated state. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. The resultant activation of calcium-dependent proteins could lead to the activation of N4bp2l1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP which activates cAMP-dependent pathways. By mimicking cAMP, it can activate PKA and subsequently lead to the activation of N4bp2l1 through phosphorylation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It is known that the inhibition of certain kinases by staurosporine can result in the altered activity of other proteins and kinases, potentially leading to the activation of N4bp2l1 through complex kinase interactions. | ||||||