N-type Ca++ CP α1B Activators
The class of CACNA1B activators comprises a diverse array of compounds that modulate the activity of voltage-gated calcium channels, particularly those encoded by the CACNA1B gene. These activators play a pivotal role in enhancing calcium influx into cells, impacting neuronal excitability, neurotransmitter release, and muscle contraction. One notable member is Bay K8644, a calcium channel activator that selectively enhances L-type channel activity, including those associated with CACNA1B. Its mechanism involves increasing channel open probability, leading to elevated calcium entry and modulation of cellular functions. FPL 64176, although primarily an inhibitor, can also act as an activator by modulating L-type calcium channels, including those encoded by CACNA1B. Its dual role highlights the intricate regulatory mechanisms governing calcium channel activity. Another compound, (-)-Bay K 8644, an enantiomer of Bay K8644, acts as a calcium channel activator by selectively enhancing L-type calcium channel activity, influencing cellular excitability.
(+)-SKF 96365, while known for blocking receptor-operated calcium channels, activate CACNA1B by influencing calcium signaling pathways. Its mechanism involves altering calcium dynamics, which may indirectly impact CACNA1B and cellular responses to calcium influx. YM-58483, a calcium-activated potassium channel modulator, indirectly influences CACNA1B by affecting potassium channel activity, influencing membrane potential, and calcium channel kinetics. BAY 58-2667, a nitric oxide-independent activator of soluble guanylate cyclase, indirectly modulates CACNA1B through downstream effects on cGMP signaling. Isoproterenol, a beta-adrenergic receptor agonist, activates CACNA1B indirectly through cAMP signaling, demonstrating the interconnectedness of signaling pathways influencing calcium channel activity. Niflumic acid, while primarily known as a calcium-activated chloride channel inhibitor, activate CACNA1B by influencing membrane potential and calcium channel kinetics. 1,25-Dihydroxyvitamin D3, the active form of vitamin D, can modulate calcium homeostasis and activate CACNA1B through genomic pathways, influencing the expression of calcium-handling proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is a calcium channel activator that enhances calcium influx through L-type channels, including CACNA1B. By increasing channel open probability, it modulates cellular excitability, impacting neurotransmitter release and muscle contraction. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176, besides its inhibitory role, can also act as an activator. It modulates L-type calcium channels, including those encoded by CACNA1B, leading to increased calcium entry and enhanced cellular excitability, influencing various physiological processes. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
(+)-SKF 96365 is a compound that influences calcium signaling pathways, potentially activating CACNA1B. Its mechanism involves blocking receptor-operated calcium channels, leading to altered calcium dynamics and modulation of cellular responses. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $189.00 | 9 | |
BTP2 is a calcium-activated potassium channel modulator, indirectly influencing calcium entry through CACNA1B. By affecting potassium channel activity, it can impact membrane potential and calcium channel kinetics, influencing cellular excitability. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist that can activate CACNA1B indirectly through cAMP signaling. By stimulating adenylyl cyclase, it increases cAMP levels, leading to protein kinase A (PKA) activation, which can modulate calcium channel activity. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid is an inhibitor of calcium-activated chloride channels. Its potential as an activator lies in its ability to influence membrane potential and calcium channel kinetics, indirectly impacting CACNA1B and calcium-dependent cellular processes. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
1,25-Dihydroxyvitamin D3, the active form of vitamin D, can modulate calcium homeostasis and potentially activate CACNA1B. It exerts its effects through genomic pathways, influencing the expression of calcium-handling proteins and cellular responses to calcium influx. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide, at controlled concentrations, can influence calcium signaling pathways and potentially activate CACNA1B. Its effects may involve redox modulation of proteins associated with calcium channels, leading to altered calcium dynamics and cellular responses. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 can influence calcium signaling pathways, potentially activating CACNA1B. Its effects may involve G protein-coupled receptor activation and subsequent modulation of intracellular calcium dynamics, influencing cellular responses to calcium influx. | ||||||