Date published: 2026-5-30

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Myosin IIIb Inhibitors

Myosin IIIb Inhibitors constitute a class of chemical compounds engineered to interact with and regulate the activity of the Myosin IIIb protein. Myosin IIIb, a member of the myosin superfamily, is a molecular motor protein involved in intracellular transport and cellular processes like organelle movement, actin cytoskeleton dynamics, and membrane trafficking. While the exact scope of Myosin IIIb's functions and its interactions are subjects of ongoing research, its involvement in various cellular processes underscores its significance. Inhibitors tailored for Myosin IIIb are meticulously designed to interfere with or regulate its motor activity, potentially influencing the intracellular transport and actin cytoskeleton dynamics.

The mechanism of action for Myosin IIIb inhibitors primarily revolves around their capacity to bind to the Myosin IIIb protein, with a specific focus on its motor domains or interaction sites. These interactions enable the inhibitors to disrupt or modulate the motor function of Myosin IIIb, potentially affecting intracellular transport and actin cytoskeleton dynamics within the cell. Researchers utilize Myosin IIIb inhibitors as critical tools to unravel the intricacies of myosin-driven cellular processes and to gain deeper insights into the specific roles played by Myosin IIIb in cellular physiology. By inhibiting Myosin IIIb, scientists aim to contribute to a more profound understanding of the molecular mechanisms governing intracellular transport and actin cytoskeleton dynamics, ultimately advancing the field of cell biology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-Blebbistatin

674289-55-5sc-203532B
sc-203532
sc-203532A
sc-203532C
sc-203532D
5 mg
10 mg
25 mg
50 mg
100 mg
$183.00
$313.00
$464.00
$942.00
$1723.00
7
(1)

Blebbistatin is a small molecule inhibitor that selectively inhibits non-muscle myosin II (NM II). It binds to the pocket between the upper 50kDa and the converter domain of the heavy chain of myosin II, which locks myosin in a state that cannot bind to actin.

ML-7 hydrochloride

110448-33-4sc-200557
sc-200557A
10 mg
50 mg
$91.00
$267.00
13
(1)

ML-7 is an inhibitor of myosin light chain kinase (MLCK). MLCK phosphorylates the regulatory light chain of myosin, which is a crucial step for myosin activation and subsequent actin-myosin interaction.

ML-9

105637-50-1sc-200519
sc-200519A
sc-200519B
sc-200519C
10 mg
50 mg
100 mg
250 mg
$112.00
$449.00
$673.00
$1224.00
2
(1)

Like ML-7, ML-9 is also an inhibitor of myosin light chain kinase (MLCK).

2,3-Butanedione 2-Monoxime

57-71-6sc-203774
sc-203774A
sc-203774B
sc-203774C
25 g
100 g
250 g
500 g
$42.00
$78.00
$161.00
$286.00
(1)

BDM is known to inhibit myosin ATPase activity, which in turn disrupts the actin-myosin interaction, a key component of muscle contraction.