MYH14 Inhibitors
Chemicals classified as MYH14 inhibitors would be characterized by their ability to modulate the activity of MYH14 indirectly by influencing myosin function or the related actin cytoskeleton. These compounds can impact the cellular processes MYH14 is involved in, such as cell shape maintenance, cytokinesis, and cell migration, by changing the dynamics of actin and myosin interactions.
Blebbistatin and its inactive form, (-)-Blebbistatin, can bind to myosin II and inhibit its ATPase activity, which can in turn affect the function of MYH14 in cellular contractility. ML-7 and Y-27632 target kinases directly responsible for the phosphorylation of myosin light chains and the regulation of the actomyosin cytoskeleton, respectively, influencing MYH14's role in these processes. Compounds such as CK-666 and Wiskostatin disrupt the formation of actin structures by inhibiting the Arp2/3 complex and N-WASP-Arp2/3 complex, which could lead to a decrease in MYH14's interaction with actin filaments.Additionally, SMIFH2 and BMS-5 target proteins involved in actin filament formation and regulation, such as formins and LIM kinase, which indirectly can affect MYH14's association with actin. By altering the polymerization and stabilization of actin filaments, compounds like Latrunculin A, Jasplakinolide, and Swinholide A can cause changes in cell morphology and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II ATPase activity, resulting in reduced myosin II-mediated contractility, potentially affecting MYH14 function in cells. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), which can decrease phosphorylation of myosin light chains and thereby influence MYH14 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK (Rho-associated protein kinase), which can lead to reduced tension in the actomyosin cytoskeleton, affecting MYH14-mediated processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Selectively inhibits the N-WASP-Arp2/3 complex, which can alter actin polymerization and potentially impact MYH14 function. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
Inhibits the Arp2/3 complex, which controls actin branching and thereby can affect MYH14 associated with actin filaments. | ||||||
NVP-BHG712 | 940310-85-0 | sc-364554 sc-364554A | 5 mg 50 mg | $232.00 $1764.00 | ||
Inhibits formin-mediated actin assembly, which could modulate actin structures that interact with MYH14. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers preventing polymerization, which may indirectly influence MYH14 by disrupting the actin cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments and can lead to changes in actin dynamics, potentially affecting MYH14's interactions with actin. | ||||||