Myeloid Marker Inhibitors
Myeloid Marker inhibitors are a set of chemical compounds that can potentially decrease the functional activity of the Myeloid Marker through specific signaling pathways or biological processes that it is directly involved in. Imatinib, for example, is a tyrosine-kinase inhibitor that specifically targets the BCR-ABL fusion protein, which is commonly overexpressed in myeloid cells. Its inhibition can lead to reduced proliferation and survival of cells expressing the Myeloid Marker. Similarly, Hydroxyurea inhibits ribonucleotide reductase, an enzyme required for DNA synthesis, and this inhibition can lead to a decrease in cells expressing the Myeloid Marker, given that rapidly dividing myeloid cells would be particularly affected.
On the other hand, Cytarabine and 5-Fluorouracil, which are cytosine and uracil analogs respectively, inhibit DNA synthesis by incorporating into DNA during replication and inhibiting thymidylate synthase, leading to DNA damage and cell cycle arrest. This can inhibit the proliferation of myeloid cells and decrease the expression of the Myeloid Marker. DNA damage is also induced by Etoposide and Daunorubicin, which inhibit topoisomerase II, and Azacitidine and Decitabine, which disrupt nucleic acid metabolism and induce hypomethylation by incorporating into DNA and RNA and inhibiting DNA methyltransferase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, an enzyme required for DNA synthesis. Myeloid cells undergoing rapid division would be particularly affected, leading to a decrease in cells expressing the Myeloid Marker. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a cytosine analog that gets incorporated into DNA during replication, inhibiting DNA polymerase and causing DNA damage. This can inhibit the proliferation of myeloid cells and decrease the expression of the Myeloid Marker. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a uracil analog that inhibits thymidylate synthase, disrupting DNA synthesis. This can lead to cell cycle arrest in myeloid cells and decreased expression of the Myeloid Marker. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, causing DNA damage and cell cycle arrest. This can inhibit the proliferation of myeloid cells and decrease the expression of the Myeloid Marker. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Daunorubicin intercalates into DNA, inhibiting topoisomerase II and causing DNA damage. This can inhibit the proliferation of myeloid cells and decrease the expression of the Myeloid Marker. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine is a nucleoside metabolic inhibitor that incorporates into DNA and RNA, disrupting nucleic acid metabolism and leading to cell death. This can decrease the number of myeloid cells and thus decrease the expression of the Myeloid Marker. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a cytidine analog that incorporates into DNA and inhibits DNA methyltransferase, leading to hypomethylation and cell death. This can decrease the number of myeloid cells and thus decrease the expression of the Myeloid Marker. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans Retinoic Acid modulates gene expression and promotes the differentiation of myeloid cells, which can lead to decreased proliferation and the reduced expression of the Myeloid Marker. | ||||||
PKC-412 | 120685-11-2 | sc-200691 sc-200691A | 1 mg 5 mg | $52.00 $114.00 | 10 | |
Midostaurin is a multi-target kinase inhibitor that inhibits several signaling pathways, leading to decreased proliferation and survival of myeloid cells and a decrease in the expression of the Myeloid Marker. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic Trioxide induces apoptosis and inhibits the proliferation of myeloid cells, leading to a decrease in the expression of the Myeloid Marker. | ||||||