MSE55 Activators
MSE55 Activators function by interacting with various aspects of the actin cytoskeleton, a primary cellular structure that MSE55 is known to associate with. Compounds like Latrunculin A and Cytochalasin D directly interfere with actin polymerization, which can enhance the role of MSE55 in managing the pool of G-actin and F-actin within the cell. The dynamic equilibrium between these forms ofactin is crucial for various cellular processes, and MSE55's function is intimately connected to this equilibrium. By increasing monomeric G-actin, these compounds could make more actin available for MSE55 to influence, thus enhancing its functional activity. On the other hand, Jasplakinolide and Phalloidin stabilize F-actin, which could lead to an increased demand for MSE55's actin bundling or stabilizing activity as the cell responds to the altered dynamics of actin filaments.
In addition to direct actin interactors, inhibitors of actin-related pathways also play a role in modifying MSE55 activity. For example, Y-27632, a ROCK inhibitor, can enhance MSE55 function by shifting the balance in actin dynamics towards states that require MSE55 activity. ML141, by inhibiting CDC42, may increase the availability of MSE55 for alternative interactions, thus enhancing its role in the cell. Similarly, NSC23766, by modulating Rac1 activity, indirectly affects CDC42 pathways, which could alter the function of MSE55 in actin organization. Compounds like CK-636 and SMIFH2, which inhibit the Arp2/3 complex and formin-mediated actin assembly, respectively, impact actin nucleation and elongation, enhancing the importance of MSE55 in the formation and maintenance of actin structures. Toxin B, by inactivating Rho GTPases, including CDC42, could induce compensatory mechanisms that involve MSE55. Lastly, Forskolin and Blebbistatin indirectly modulate the actin cytoskeleton via cAMP levels and myosin II ATPase activity, respectively, which in turn can enhance MSE55's role in actin cytoskeletal regulation. Each of these compounds, through their distinct interactions with cellular components, can influence the cellular environment in a way that enhances the functional activity of MSE55 by modulating the actin cytoskeleton and related signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
This compound binds to actin monomers, preventing their polymerization. As MSE55 is involved in actin cytoskeletal regulation, the inhibition of actin filament formation by Latrunculin A can enhance MSE55's role in cytoskeletal dynamics by increasing the pool of monomeric actin that MSE55 may bind to or regulate. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A cyclic peptide that stabilizes actin filaments and can lead to an increase in filamentous actin (F-actin). Since MSE55 interacts with the actin cytoskeleton, stabilization of F-actin by Jasplakinolide can enhance MSE55’s function in cells, potentially promoting its activity in actin filament bundling or stabilization. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
A potent and selective inhibitor of CDC42 GTPase, which directly interacts with MSE55. Inhibition of CDC42 could enhance the availability of MSE55 to participate in alternative interactions or functions within the cell. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
This compound disrupts actin polymerization by binding to the barbed end of growing actin filaments. By perturbing actin dynamics, Cytochalasin D can enhance the role of MSE55 in actin cytoskeletal rearrangements. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP can modulate the actin cytoskeleton and thus potentially enhance the role of MSE55 in actin dynamics. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
A toxin that binds to and stabilizes F-actin, and could thus influence the function of MSE55 by altering the dynamics of actin filaments it interacts with. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
A small molecule inhibitor of formin-mediated actin nucleation and elongation. Given MSE55’s interaction with the actin cytoskeleton, SMIFH2 can enhance MSE55's role by affecting the dynamics of actin filament formation. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
A selective inhibitor of myosin II ATPase activity, which can alter actin-myosin contractility. This alteration can enhance the role of MSE55 in regulating the architecture of the actin cytoskeleton. | ||||||