MRP-L49 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial electron transport at complex I. MRP-L49, being a mitochondrial ribosomal protein, is implicated in mitochondrial protein synthesis. Impaired electron transport can reduce the membrane potential, indirectly affecting the translation of mitochondrial-encoded proteins, thus inhibiting MRP-L49 function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III. This disruption leads to decreased ATP production and can cause a downregulation of mitochondrial protein synthesis, thereby indirectly inhibiting MRP-L49's role in mitochondrial ribosomal function. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol is known to inhibit bacterial protein synthesis. Given the similarities between bacterial ribosomes and mitochondrial ribosomes, chloramphenicol can inhibit mitochondrial protein synthesis, affecting MRP-L49's function in the mitochondrial ribosome. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline binds to the 30S subunit of bacterial ribosomes, and similarly, it can bind to the mitochondrial ribosome, potentially inhibiting MRP-L49's role in the assembly and function of the mitochondrial ribosome. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin inhibits ATP synthase, reducing ATP levels and thus can indirectly inhibit the energy-dependent process of mitochondrial protein synthesis where MRP-L49 functions. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Actinonin is a peptide antibiotic that inhibits peptide deformylase, an enzyme involved in protein maturation in mitochondria. This can lead to a backlog of immature proteins, indirectly affecting MRP-L49's role in proper mitochondrial protein synthesis. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Zidovudine is a nucleoside analogue reverse transcriptase inhibitor that can incorporate into mitochondrial DNA, potentially causing mitochondrial toxicity and thereby indirectly inhibiting MRP-L49 by impairing mitochondrial protein synthesis. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits RNA polymerase II. While MRP-L49 is not directly involved in RNA synthesis, impaired transcription in the nucleus can indirectly affect the translation process in mitochondria where MRP-L49 is active. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin binds to the 50S subunit of bacterial ribosomes, and by analogy, it can affect the mitochondrial ribosome and inhibit MRP-L49's function in mitochondrial protein synthesis. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
ABT-199 is a Bcl-2 inhibitor that can induce apoptosis, potentially leading to a decrease in mitochondrial function and indirectly affecting MRP-L49 by reducing the demand for mitochondrial protein synthesis. | ||||||