MIS Activators

Common MIS Activators include, but are not limited to Diethylstilbestrol CAS 56-53-1, Di-n-butyl phthalate CAS 84-74-2, Letrozole CAS 112809-51-5, Clomiphene Citrate CAS 50-41-9 and Ketoconazole CAS 65277-42-1.

MIS, also referred to as anti-Müllerian hormone (AMH), is a glycoprotein hormone of the transforming growth factor-beta (TGF-β) family. It plays an essential role in male and female reproductive development. In males, MIS is responsible for the regression of the Müllerian ducts, structures that would otherwise develop into the female reproductive tract. In females, AMH is produced by the granulosa cells of ovarian follicles and serves as a marker of ovarian reserve, reflecting the number of remaining egg-containing follicles in the ovaries. The level of AMH in a woman's blood is often used as an indicator of her ovarian function, fertility, and the onset of menopause.

The chemical class of MIS Activators encompasses molecules designed to enhance the expression, release, or activity of MIS/AMH. These activators might function by stimulating the transcription of the MIS/AMH gene, promoting the secretion of the hormone, or increasing its binding and activity at its receptors. By amplifying the effects of MIS/AMH, these activators can modulate reproductive developmental processes, especially those where the hormone naturally has a regulatory role. In a research context, MIS/AMH activators can be valuable tools for probing the hormone's functions in reproductive biology and its interactions with other hormonal pathways. Investigating these activators helps in elucidating the intricate balance of factors that govern reproductive development and function, offering deeper insights into the complexities of human biology at the molecular and cellular levels.