MIP-2α Inhibitors
MIP-2α inhibitors are a class of compounds that target the modulation of macrophage inflammatory protein 2-alpha (MIP-2α), also known as CXCL2. MIP-2α is a chemokine that plays a key role in the recruitment and activation of neutrophils, particularly in inflammatory environments. As part of the larger CXC chemokine family, MIP-2α exerts its influence through the binding and activation of the CXCR2 receptor, a G-protein coupled receptor expressed on the surface of certain immune cells. Inhibitors of MIP-2α function by interfering with the interaction between MIP-2α and CXCR2, thereby modulating the signaling cascade that typically results in immune cell recruitment and subsequent inflammatory responses. These inhibitors may act through different mechanisms, including competitive binding to CXCR2, direct neutralization of MIP-2α, or allosteric modulation of receptor activity, ultimately leading to altered chemotactic signaling.
Structurally, MIP-2α inhibitors can vary widely, ranging from small organic molecules to peptides and larger biologics designed to disrupt the MIP-2α/CXCR2 interaction. The design of such inhibitors often relies on the structural characterization of both the chemokine and receptor, utilizing techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) to identify critical interaction sites. Furthermore, molecular docking studies and in vitro binding assays are frequently employed to screen for potential inhibitors with high specificity and affinity for CXCR2. The development of MIP-2α inhibitors requires careful consideration of their pharmacokinetic properties, such as solubility, stability, and bioavailability, which are crucial for ensuring effective modulation of the chemokine-receptor pathway under controlled conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may downregulate MIP-2α expression by binding to glucocorticoid receptors, which then translocate to the nucleus and interfere with the transcription factors such as AP-1 and NF-κB, directly repressing the genes responsible for MIP-2α production. | ||||||
SB 225002 | 182498-32-4 | sc-202803 sc-202803A | 1 mg 5 mg | $35.00 $100.00 | 2 | |
SB 225002 likely reduces MIP-2α expression by competitively binding to the CXCR2 receptor, hindering the receptor-mediated signaling cascade that normally results in the upregulation of MIP-2α gene transcription. | ||||||
Reparixin | 266359-83-5 | sc-507446 | 5 mg | $76.00 | ||
Reparixin can decrease MIP-2α expression by blocking the interaction between CXCR1/CXCR2 receptors and their ligands, thus diminishing the autocrine and paracrine signaling that upholds MIP-2α synthesis by inflammatory cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin may reduce MIP-2α expression by hindering the phosphorylation of IκB, thereby preventing the release and nuclear translocation of NF-κB, a key transcription factor for MIP-2α gene expression. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide could decrease MIP-2α expression by directly binding to NF-κB's p50 subunit, disrupting the NF-κB dimer formation, and attenuating the transcriptional activity of NF-κB responsive genes, including those for MIP-2α. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is likely to inhibit MIP-2α expression by blocking the activation of the NF-κB pathway through the suppression of IKK activity, leading to the stabilization of IκB and subsequent inhibition of NF-κB's transcriptional activity on the MIP-2α gene. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin has the potential to reduce MIP-2α expression by inhibiting the phosphorylation of the MAPKs, which are upstream regulators of transcription factors like NF-κB that drive the production of MIP-2α. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin may downregulate MIP-2α expression by suppressing the JAK/STAT signaling pathway, which is involved in the intracellular signaling cascade that leads to the synthesis of MIP-2α. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin could inhibit MIP-2α expression by blocking the activity of PI3K/Akt, a pathway that, when activated, typically enhances the transcription of a multitude of inflammatory cytokines, including MIP-2α. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may decrease MIP-2α expression by inhibiting the activation of SIRT1, a deacetylase that, upon activation, can promote the transcription of various pro-inflammatory cytokines including MIP-2α. | ||||||