MIA (MIA SH3 domain containing) activators are a group of molecules that play a crucial role in regulating specific cellular processes by interacting with proteins containing SH3 (Src homology 3) domains. SH3 domains are conserved protein domains found in a variety of signaling proteins, and they are involved in mediating protein-protein interactions. MIA activators are typically small organic molecules or peptides that can bind to and modulate the activity of proteins with SH3 domains, thereby influencing intracellular signaling pathways and cellular responses. The name "MIA" is found in the acronym for the MIA SH3 domain-containing proteins, which are a group of signaling molecules known to interact with SH3 domain-containing proteins.
The interaction between MIA activators and proteins containing SH3 domains is a highly specific and regulated process. MIA activators often function as molecular switches, fine-tuning the activation or inhibition of downstream signaling cascades. This interaction is crucial for the regulation of processes such as cell growth, differentiation, and intracellular trafficking. By targeting proteins with SH3 domains, MIA activators have the capacity to modulate various cellular pathways, ultimately affecting cell behavior and function. Understanding the mechanisms and functions of MIA activators is of great interest in the field of cell biology and molecular biology, as it sheds light on the intricate control mechanisms that govern essential cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A vitamin A derivative that engages the retinoic acid signaling pathway, potentially directly or indirectly activating MIA. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-beta receptor, employed to study TGF-beta signaling's role in the activation of MIA-related processes. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
An inhibitor of Wnt signaling used to stimulate the Wnt pathway's involvement with MIA, potentially activating it. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that engages with the PI3K-Akt signaling pathway, indirectly spurring MIA activation by impacting relevant cellular processes. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
An inhibitor of Hedgehog signaling that interacts with the Hedgehog pathway, potentially promoting MIA activation indirectly. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An inhibitor of NF-κB signaling, interacting with processes related to inflammation and immunity, which can indirectly activate MIA. | ||||||