MGAT3 Inhibitors
MGAT3 inhibitors are a class of chemical compounds that specifically target and inhibit the function of MGAT3, an enzyme known as mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase. MGAT3 plays a critical role in the process of N-linked glycosylation, a biochemical pathway that adds complex sugar chains (glycans) to proteins, influencing their structure, function, and stability. Specifically, MGAT3 is responsible for catalyzing the addition of a bisecting N-acetylglucosamine (GlcNAc) to the core of N-glycans, which impacts protein folding, cellular interactions, and receptor binding. Inhibiting MGAT3 allows researchers to explore how changes in glycan branching and composition affect cellular processes such as protein trafficking, immune recognition, and intercellular communication.
The mechanism of action for MGAT3 inhibitors typically involves blocking the enzyme's active site, preventing it from attaching GlcNAc to its glycoprotein substrates. These inhibitors are often designed to mimic the natural substrates of MGAT3 or the intermediate structures involved in the glycosylation reaction, enabling them to competitively inhibit the enzyme's activity. Structurally, MGAT3 inhibitors may also work by binding to allosteric sites on the enzyme, causing conformational changes that reduce its catalytic efficiency. By utilizing MGAT3 inhibitors, researchers gain insights into the regulatory role of N-glycan modification in cell signaling and protein function, helping to unravel the complex network of interactions governed by glycosylation. These inhibitors are valuable tools for investigating the role of specific glycan structures in maintaining cellular homeostasis, protein interactions, and the broader implications of glycan-mediated cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may downregulate MGAT3 expression by inducing hypomethylation of its gene promoter, thereby disrupting the normal epigenetic silencing mechanisms that control gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could decrease MGAT3 expression by inducing hyperacetylation of histones associated with the gene, thereby compacting chromatin structure to a state less conducive to transcriptional activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
By directly targeting DNA methyltransferases, RG108 may reduce the methylation level of CpG islands near the MGAT3 gene, leading to a decrease in the gene's expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine could decrease MGAT3 expression through the inhibition of DNA methylation, which may result in the activation of previously silenced regulatory regions upstream of the MGAT3 gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may downregulate MGAT3 expression by inhibiting mTOR signaling, which often leads to a general reduction in the transcriptional activity of genes involved in cell proliferation and growth. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 could downregulate MGAT3 expression by inhibiting PI3K, thereby reducing the downstream signaling necessary for the transcriptional activation of MGAT3 in response to growth factors. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
Wnt-C59 may inhibit the Wnt/β-catenin pathway, leading to the downregulation of target genes, including MGAT3, by preventing the accumulation of β-catenin that normally upregulates gene transcription. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 could decrease MGAT3 expression by inhibiting TGF-β signaling, which may otherwise enhance MGAT3 expression through its role in regulating cellular differentiation and proliferation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT could inhibit the Notch signaling pathway, leading to a reduction in MGAT3 expression due to decreased activation of Notch-responsive elements within the MGAT3 promoter region. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 may reduce MGAT3 expression by inhibiting MEK1/2, which are critical components of the ERK/MAPK signaling pathway that can drive the transcriptional activation of numerous genes, including MGAT3. | ||||||