Mfn1 Activators
Common Mfn1 Activators include, but are not limited to Resveratrol CAS 501-36-0, 1,1-Dimethylbiguanide, Hydrochloride CAS 1115-70-4, Mdivi-1 CAS 338967-87-6, Rapamycin CAS 53123-88-9 and β-Estradiol CAS 50-28-2.
Mitofusin 1 (Mfn1) is a key protein integral to the intricate world of mitochondrial dynamics. Mitochondria, often dubbed the powerhouses of the cell, are not static entities; they constantly undergo fusion and fission, processes that are vital for maintaining mitochondrial health, function, and distribution. Mfn1, along with its closely related counterpart Mfn2, is primarily involved in the fusion of the outer mitochondrial membrane. This GTPase protein facilitates the tethering and subsequent fusion of mitochondria, ensuring the maintenance of a functional mitochondrial network within cells. Fusion events, orchestrated by Mfn1, are crucial for various reasons: they enable the mixing of mitochondrial contents, help in the repair of damaged mitochondria by merging with healthy counterparts, and play a role in cellular energy distribution and metabolic regulation. The significance of Mfn1 extends beyond mere mitochondrial morphology, impacting cellular bioenergetics, calcium homeostasis, and even cell fate decisions.
Activators of Mfn1 are molecules or compounds that enhance the expression or activity of the Mfn1 protein. These activators might function by promoting Mfn1 transcription, stabilizing its protein structure, or bolstering its GTPase activity essential for mitochondrial tethering and fusion. The presence of Mfn1 activators can amplify mitochondrial fusion events, influencing the overall health and function of the mitochondrial network within cells. Venturing into the domain of Mfn1 activators offers a comprehensive understanding of the delicate equilibrium of mitochondrial dynamics and the molecular choreography that sustains cellular energy balance. As our knowledge of cellular metabolism and organelle interplay expands, the role of Mfn1 and its activators stands as a testament to the intricate dance of proteins that ensure cellular vitality and homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to promote mitochondrial fusion by upregulating MFN1 and MFN2 expression, possibly through the activation of SIRT1 and PGC-1α. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin, an antidiabetic suggested compound, may enhance mitochondrial fusion by increasing MFN1 and MFN2 expression, potentially through the AMPK pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, has been shown to influence mitochondrial dynamics, which might indirectly affect MFN1 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol has been shown to promote mitochondrial fusion in cortical neurons, potentially by upregulating MFN1. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
In some contexts, LPS has been shown to decrease MFN1 expression, suggesting a role in mitochondrial dynamics. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone, a mitochondrial complex I inhibitor, can influence mitochondrial dynamics and may affect MFN1 expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine might influence mitochondrial fusion and fission processes, potentially affecting MFN1 expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid has been shown to promote neurite outgrowth through the upregulation of MFN1 in certain neuronal cells. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $65.00 $73.00 $218.00 $697.00 $1196.00 $3574.00 | 16 | |
Melatonin has protective effects on mitochondrial function and might influence MFN1 expression and mitochondrial fusion. | ||||||