METTL24 Activators
The category METTL24 Activators represents a selection of chemicals that primarily influence kinase and phosphatase activity to modulate METTL24. Both Forskolin and 8-Bromo-cAMP serve as cAMP regulators, aiming to activate the PKA pathway. Activation of PKA can influence the transcription factors that modulate METTL24 expression, thereby indirectly activating the protein. Another approach is via the inhibition of phosphatases. Chemicals such as Calyculin A and Okadaic Acid inhibit PP1 and PP2A, respectively. These inhibitors maintain an overall phosphorylated state of proteins, which has been associated with METTL24 activation.
Other chemicals like Rapamycin and Resveratrol are more focused on cellular processes such as autophagy and protein deacetylation. Rapamycin, an mTOR inhibitor, can influence autophagy-related pathways. In this cellular state, METTL24 is often modulated to be more active. Resveratrol is a SIRT1 activator, leading to the deacetylation of proteins, which in turn can influence the activation of METTL24. Both avenues offer alternative strategies to kinase and phosphatase modulation, providing a comprehensive approach to METTL24 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, raising cAMP levels and triggering PKA activation which can modulate transcription factors for METTL24. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that enhances PKA activity, which can activate downstream factors that modulate METTL24 expression. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Inhibits cAMP and cGMP phosphodiesterases, prolonging PKA activity that can influence METTL24 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates PKC, affecting downstream pathways that can result in the modulation of METTL24. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, leading to phosphorylation states that can activate METTL24. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Blocks PP1 and PP2A, sustaining phosphorylation states that can activate METTL24. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, thereby influencing autophagy-related pathways that can indirectly modulate METTL24 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1, leading to the deacetylation of proteins that influence METTL24 activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Triggers the JNK pathway, affecting downstream factors that can lead to METTL24 activation. | ||||||