METT11D1 inhibitors encompass a range of compounds that exert their inhibitory effects through various mechanisms, impacting the methylation processes that the METT11D1 enzyme typically governs. Some of these compounds function by depleting the pool of methyl donors necessary for METT11D1's enzymatic activity; when these donors are scarce, the methyltransferase activity of METT11D1 is compromised. Other inhibitors act as competitive antagonists, occupying the binding sites that METT11D1 would typically interact with, thereby obstructing its ability to carry out methylation reactions. Further, certain inhibitors may accumulate as byproducts of methylation reactions, leading to product feedback inhibition that can prevent METT11D1 from further modifying its substrates.
Additionally, some METT11D1 inhibitors work by altering the overall methylation landscape within the cell. These compounds integrate into the DNA or RNA, where they trap other methyltransferases or incorporate aberrantly, thereby altering the methylation patterns that METT11D1 might otherwise influence. This can lead to changes in gene expression that indirectly inhibit METT11D1's function. Moreover, a subset of these compounds can demethylate DNA, leading to changes in the epigenetic regulation of genes, including those that may control the expression or function of METT11D1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
Serves as a methyl donor in methyltransferase reactions, including those mediated by METT11D1. Inhibition of METT11D1 can be achieved by depleting the availability of this compound, thus impeding the protein's methyltransferase activity. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
Can inhibit methionine adenosyltransferase, reducing levels of S-Adenosylmethionine and thereby indirectly inhibiting METT11D1's methyltransferase function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytosine analog that incorporates into DNA and inhibits DNA methyltransferases. This can indirectly affect METT11D1 by altering the epigenetic landscape and potentially changing the protein's substrate availability or expression levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog that acts as a DNA methylation inhibitor, indirectly impacting METT11D1 by modifying the epigenetic environment in which it operates, potentially affecting its function. | ||||||
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $117.00 $357.00 | ||
Inhibits S-Adenosyl-L-homocysteine hydrolase, increasing levels of S-Adenosyl-L-homocysteine, a strong feedback inhibitor of S-Adenosylmethionine-dependent methyltransferases, including METT11D1. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Inhibits DNA methyltransferases, which could lead to hypomethylation and indirect inhibition of METT11D1 by changing the epigenetic state of its substrates or modifying the expression of genes that regulate METT11D1's activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that can change the methylation status of DNA, potentially affecting the function of METT11D1 by altering the accessibility of its substrates or by modifying its expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Acts as a sirtuin inhibitor, which may indirectly influence METT11D1 activity by affecting the acetylation status of histones and other proteins, thereby possibly affecting METT11D1's regulatory mechanisms or expression levels. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
An inhibitor of G9a and GLP histone methyltransferases that could indirectly inhibit METT11D1 by altering histone methylation patterns and thereby affecting the transcriptional regulation of genes involved in METT11D1's functional pathways. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
A specific inhibitor of histone methyltransferase SUV39H1; by modifying histone methylation, it may indirectly influence the activity of METT11D1 through changes in chromatin structure, affecting gene expression or the protein's substrate specificity. | ||||||