Metallothionein 1A Activators
Metallothionein 1A activators are a class of chemical compounds that play a crucial role in modulating the expression and function of Metallothionein 1A (MT1A), a protein found in various tissues of living organisms, particularly in the liver and kidneys of mammals. MT1A is a small, cysteine-rich protein that possesses a high affinity for binding to essential metal ions such as zinc, copper, and cadmium. It serves as a critical component in the homeostasis of these metals, acting as a metal-binding and detoxification agent within the body. The activators of MT1A are a group of molecules known for their ability to enhance the transcription of MT1A gene, ultimately leading to increased production of the MT1A protein.
The primary function of MT1A activators is to regulate the intracellular levels of essential metals. These activators bind to specific regulatory elements in the promoter region of the MT1A gene, thus promoting the transcription of MT1A mRNA. As a result, there is an elevated synthesis of the MT1A protein, which can subsequently bind to and sequester metal ions within cells. This action is particularly vital in protecting cells from metal-induced toxicity, as excessive levels of certain metals can lead to oxidative stress and cellular damage. Furthermore, MT1A and its activators are involved in metal homeostasis, immune response, and the maintenance of cellular redox balance, making them essential components in the overall health and well-being of an organism. In conclusion, Metallothionein 1A activators are a class of chemical compounds that facilitate the regulation of metal ion levels in cells by enhancing the expression of the MT1A gene, ultimately contributing to metal detoxification and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions directly bind to Metallothionein 1A, leading to its structural stabilization and activation. This interaction specifically enhances the metal-binding capacity of Metallothionein 1A, facilitating its role in metal ion homeostasis and detoxification. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium ions interact with Metallothionein 1A, promoting its conformational change and activation. This binding is crucial for Metallothionein 1A’s role in sequestering toxic metals, thereby participating in cellular detoxification processes. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions bind to Metallothionein 1A, triggering its activation. This engagement is essential for the protein's function in copper regulation and detoxification, highlighting its role in maintaining metal ion equilibrium within cells. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium compounds can indirectly activate Metallothionein 1A by contributing to oxidative stress, which in turn upregulates the protein’s expression and functional activity in scavenging reactive oxygen species and detoxifying heavy metals. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $114.00 $378.00 $1081.00 | 1 | |
Silver ions form complexes with Metallothionein 1A, facilitating its activation. This interaction underscores Metallothionein 1A’s capacity to bind and neutralize various metal ions, playing a pivotal role in the detoxification pathway. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic binding activates Metallothionein 1A by promoting its capacity to chelate arsenic ions. This mechanism is crucial for reducing arsenic toxicity and facilitating its excretion from the body. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions interact with Metallothionein 1A, activating its metal-binding functions. This process is vital for the detoxification of manganese, illustrating Metallothionein 1A’s role in metal ion homeostasis. | ||||||
Lead (II) nitrate | 10099-74-8 | sc-211724 sc-211724A | 100 g 500 g | $40.00 $88.00 | ||
Lead ions binding to Metallothionein 1A activate the protein, enhancing its ability to sequester lead. This interaction is key to preventing lead-induced toxicity, showcasing Metallothionein 1A’s protective role against heavy metal poisoning. | ||||||
Nickel Sulfate | 7786-81-4 | sc-507407 | 5 g | $63.00 | ||
Nickel ions binding to Metallothionein 1A trigger its activation, emphasizing the protein’s role in nickel detoxification. This interaction illustrates Metallothionein 1A’s capacity to mitigate nickel toxicity by sequestering nickel ions. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt ions directly activate Metallothionein 1A, facilitating its function in cobalt ion detoxification. This specific activation process highlights Metallothionein 1A’s role in managing cobalt-induced cellular stress. | ||||||