MCP-1 Inhibitors
MCP-1 Inhibitors are a specialized chemical class of compounds designed to selectively target and modulate the activity of MCP-1, or Monocyte Chemoattractant Protein-1. MCP-1, also known as CCL2 (C-C motif chemokine ligand 2), is a chemokine, a type of signaling protein involved in immune responses and inflammation. Structurally, MCP-1 belongs to the chemokine family and contains characteristic conserved cysteine residues. Its primary role is to act as a chemoattractant, guiding immune cells, particularly monocytes, to sites of infection or tissue damage in response to various stimuli.
The functions of MCP-1 are integral to the immune system's ability to recruit immune cells to sites of injury or infection. Upon activation by inflammatory signals, cells in the affected tissue release MCP-1, which acts as a signaling molecule to attract monocytes and other immune cells to the site of inflammation. This recruitment process is essential for the body's defense against pathogens and for the resolution of tissue damage. MCP-1 Inhibitors are typically small molecules or compounds designed to interfere with the binding of MCP-1 to its receptor, CCR2 (C-C chemokine receptor 2), or disrupt downstream signaling pathways. By modulating MCP-1 activity, these inhibitors can influence immune cell migration and the inflammatory response, providing valuable tools for researchers studying immune regulation and the mechanisms underlying inflammatory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bindarit | 130641-38-2 | sc-503560 | 5 mg | $380.00 | ||
Bindarit selectively inhibits MCP-1 synthesis. It hampers MCP-1 production by blocking the NF-kB signaling pathway, which is essential for the transcription of MCP-1 gene. | ||||||
Bis(2-carboxyethylgermanium(IV) sesquioxide) | 12758-40-6 | sc-227361 | 5 g | $76.00 | ||
Bis(2-carboxyethylgermanium(IV) sesquioxide) is known to inhibit the production of MCP-1. It targets the production process at the transcriptional level, leading to decreased MCP-1 expression. | ||||||
Tetrandrine | 518-34-3 | sc-201492 sc-201492A | 100 mg 250 mg | $56.00 $100.00 | 9 | |
Tetrandrine, a bisbenzylisoquinoline alkaloid, has shown potential to inhibit MCP-1 production in certain inflammatory models. It may exert its effect by suppressing related signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been shown to inhibit MCP-1 expression in various cell types. It might mediate this effect by suppressing the NF-κB pathway, a key regulator of MCP-1 transcription. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, an antioxidant, can potentially decrease MCP-1 levels. Its antioxidant properties might contribute to the down-regulation of MCP-1 by quenching oxidative stress, which can induce MCP-1 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPARγ agonist, has shown potential to inhibit MCP-1 production. The activation of PPARγ can lead to the transcriptional repression of inflammatory genes, including MCP-1. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may reduce MCP-1 production through its anti-inflammatory properties. By inhibiting the COX pathway, it can lead to reduced synthesis of pro-inflammatory mediators that upregulate MCP-1. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits NF-κB activation, which is pivotal for MCP-1 transcription. Thus, it can potentially down-regulate MCP-1 expression by inhibiting this pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane has been shown to inhibit MCP-1 expression in various studies. Its potential antioxidative and anti-inflammatory properties might contribute to decreased MCP-1 production. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can down-regulate MCP-1 expression, potentially by inhibiting the NF-κB pathway. Its broad anti-inflammatory effects can contribute to reduced MCP-1 levels. | ||||||