Date published: 2026-1-21

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MCH-1R Inhibitors

Melanin-concentrating hormone receptor 1 (MCH-1R) is a protein that belongs to the G-protein coupled receptor (GPCR) family. It is primarily expressed in the central nervous system, specifically in regions involved in the regulation of energy homeostasis, such as the lateral hypothalamus and the limbic system. MCH-1R is the receptor for melanin-concentrating hormone (MCH), a neuropeptide that plays a role in regulating feeding behavior, energy balance, and the sleep-wake cycle. When MCH binds to MCH-1R, it activates intracellular signaling pathways that modulate the release of other neurotransmitters and hormones involved in appetite regulation. MCH-1R is primarily coupled to the Gαi/o class of G-proteins, which leads to the inhibition of adenylyl cyclase and a decrease in cyclic adenosine monophosphate (cAMP) levels. This signaling pathway ultimately leads to the modulation of neuronal activity and influences the release of various neurotransmitters, including dopamine, serotonin, and gamma-aminobutyric acid (GABA).MCH-1R activation promotes feeding behavior by increasing appetite and food intake. It stimulates the reward pathway in the brain, leading to the perception of food as pleasurable and reinforcing the desire to eat. MCH-1R signaling also influences energy expenditure and metabolism by regulating sympathetic outflow and altering thermogenesis in adipose tissue. Moreover, MCH-1R is involved in the regulation of sleep-wake cycles. MCH, acting through MCH-1R, promotes non-rapid eye movement (NREM) sleep and inhibits rapid eye movement (REM) sleep, thus modulating the sleep architecture.In summary, Melanin-concentrating hormone receptor 1 (MCH-1R) is a G-protein coupled receptor primarily expressed in the central nervous system. It plays a crucial role in the regulation of energy homeostasis, appetite, and sleep-wake cycles. MCH-1R inhibitors offered by Santa Cruz Biotechnology inhibit MCH-1R and, in some cases, other hormone receptors.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SNAP 94847 hydrochloride

487051-12-7sc-311536
sc-311536A
10 mg
50 mg
$199.00
$825.00
(0)

SNAP 94847 hydrochloride acts as a selective antagonist of the MCH-1R receptor, demonstrating a distinctive binding affinity that disrupts typical receptor activation. Its molecular structure facilitates specific hydrogen bonding and hydrophobic interactions, which modulate receptor conformation. This compound influences the kinetics of receptor-ligand interactions, leading to altered signaling dynamics and downstream effects on cellular processes. Its unique characteristics enhance its role in receptor modulation.

ATC 0065

510732-84-0sc-358785
sc-358785A
10 mg
50 mg
$350.00
$1200.00
(0)

ATC 0065 functions as a selective modulator of the MCH-1R receptor, exhibiting a unique interaction profile characterized by its ability to stabilize specific receptor conformations. The compound engages in intricate van der Waals forces and electrostatic interactions, which fine-tune the receptor's activity. Its kinetic properties allow for rapid association and dissociation rates, influencing the overall signaling cascade and cellular response mechanisms. This distinct behavior underscores its role in receptor dynamics.

ATC0175

510733-97-8sc-252391
10 mg
$520.00
(0)

ATC0175 acts as a selective antagonist of the MCH-1R receptor, showcasing a unique binding affinity that alters receptor dynamics. Its molecular structure facilitates specific hydrogen bonding and hydrophobic interactions, leading to a conformational shift in the receptor. This compound exhibits notable reaction kinetics, with a delayed onset of action that allows for prolonged receptor modulation. The distinct interaction profile of ATC0175 contributes to its nuanced impact on downstream signaling pathways.

GW 803430

515141-51-2sc-363281
sc-363281A
10 mg
50 mg
$245.00
$982.00
(1)

GW 803430 functions as a selective antagonist of the MCH-1R receptor, characterized by its unique ability to disrupt receptor-ligand interactions. Its molecular architecture promotes specific electrostatic and van der Waals forces, resulting in a significant alteration of receptor conformation. The compound demonstrates a unique kinetic profile, exhibiting a gradual dissociation rate that enhances its modulatory effects on receptor activity, ultimately influencing various intracellular signaling cascades.