MAT Iα Activators
Methionine Adenosyltransferase Iα (MAT Iα) is a pivotal enzyme in the metabolic pathways, primarily responsible for the biosynthesis of S-adenosylmethionine (SAMe), a critical methyl donor involved in numerous cellular processes. This enzyme catalyzes the reaction between methionine and ATP to produce SAMe, facilitating a wide array of transmethylation reactions essential for the synthesis of nucleic acids, proteins, phospholipids, and neurotransmitters. The activity of MAT Iα is vital for the maintenance of cellular methylation status and liver function, where it plays a significant role in detoxification processes, lipid metabolism, and the regeneration of hepatocytes. The regulation of MAT Iα activity ensures a balanced supply of SAMe, which is crucial for cell growth, differentiation, and the prevention of liver diseases. Given its central role in methionine metabolism, MAT Iα serves as a key regulatory point in maintaining cellular homeostasis and responding to metabolic demands.
The activation of MAT Iα is regulated through a complex interplay of biochemical and physiological signals that ensure its activity is aligned with the cellular requirements for SAMe. Factors that influence MAT Iα activation include substrate availability, with methionine levels acting as a direct regulator of its enzymatic action. Additionally, the cellular energy status, indicated by ATP levels, plays a crucial role in modulating MAT Iα activity. Beyond substrate availability, post-translational modifications, such as phosphorylation, can alter the conformation of MAT Iα, enhancing its catalytic efficiency or stability. Furthermore, the expression of MAT Iα is subject to regulation by nutritional and hormonal signals, which adjust the enzyme's synthesis according to the metabolic state of the cell. This intricate regulation of MAT Iα ensures that SAMe production is tightly controlled, reflecting the enzyme's importance in a wide range of cellular functions and its adaptive response to metabolic needs. Understanding the mechanisms underlying MAT Iα activation provides valuable insights into cellular metabolism and the potential impact of its dysregulation on human health.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe is a naturally occurring compound and the primary methyl donor in cellular methylation reactions. As MAT Iα catalyzes the synthesis of SAMe from methionine, increased availability of SAMe may directly activate MAT Iα by providing a substrate for the enzymatic reaction. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine is involved in the methionine cycle and can donate a methyl group to homocysteine, a reaction catalyzed by betaine-homocysteine methyltransferase. By influencing methionine cycle intermediates, betaine may indirectly activate MAT Iα by modulating the availability of substrates and products in the interconnected metabolic pathways. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine is an essential amino acid and a precursor for SAMe synthesis. Increased levels of methionine in the cellular environment may directly activate MAT Iα by providing a substrate for the enzymatic reaction. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal-5-phosphate is the active form of vitamin B6 and acts as a cofactor for various enzymes, including those involved in amino acid metabolism. By influencing the activity of these enzymes, vitamin B6 may indirectly activate MAT Iα by modulating the availability of substrates and products in the interconnected metabolic pathways. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid is a precursor for tetrahydrofolate, a cofactor involved in one-carbon metabolism. By participating in one-carbon metabolism, folic acid may indirectly activate MAT Iα by influencing the availability of methyl donors and acceptors in the cellular environment. | ||||||
Choline base solution | 123-41-1 | sc-239545 | 100 ml | $79.00 | ||
Choline is a precursor for betaine, and its metabolism is linked to the methionine cycle. By providing substrates for methionine cycle reactions, choline may indirectly activate MAT Iα by modulating the availability of methyl donors and acceptors in the interconnected metabolic pathways. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine is a nucleoside and a component of SAMe. By providing a precursor for SAMe synthesis, increased levels of adenosine may directly activate MAT Iα by contributing to the enzymatic reaction. | ||||||
DL-Methionine | 59-51-8 | sc-397777 | 100 g | $45.00 | ||
MSO is an analog of methionine and a known inhibitor of MAT Iα. Despite its inhibitory nature, low concentrations of MSO may paradoxically lead to the activation of MAT Iα by acting as a substrate and enhancing the enzyme's catalytic activity. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $122.00 | 1 | |
MTA is generated as a byproduct of polyamine synthesis and can inhibit MAT Iα. Despite its inhibitory nature, low concentrations of MTA may paradoxically activate MAT Iα by acting as a substrate and enhancing the enzyme's catalytic activity. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
AdoHcy is a byproduct of SAMe-dependent methylation reactions and a known inhibitor of MAT Iα. However, at lower concentrations, AdoHcy may serve as a feedback signal and potentially activate MAT Iα by modulating the enzyme's regulatory mechanisms. | ||||||