LYRM5 Inhibitors
Chemical inhibitors of LYRM5 function by disrupting various components of the mitochondrial electron transport chain, where LYRM5 is essential for electron transfer and energy production. Rotenone and Piericidin A directly target complex I, where LYRM5 operates, by inhibiting the normal electron flow through this complex, resulting in a cessation of the electron transfer process that LYRM5 is a part of. Similarly, Carboxin and Thenoyltrifluoroacetone (TTFA) affect complex II, which, although not directly involving LYRM5, can lead to a secondary reduction in complex I activity due to the interdependence of the complexes in the electron transport chain. This interdependence means that inhibition of one complex can impact the function of another, thereby indirectly reducing LYRM5's role.
Furthermore, Atovaquone and Antimycin A impact complex III, leading to an upstream inhibition of complex I by causing a backlog of electrons, which, in turn, affects LYRM5's function. Sodium azide and potassium cyanide inhibit complex IV, which can cause a decrease in electron transport chain activity overall. This decrease can indirectly inhibit LYRM5 by limiting its necessity in the electron transfer process. Oligomycin A targets ATP synthase, complex V, and the resulting drop in ATP production can lead to a reduced demand for electron transport via complex I, indirectly affecting LYRM5. Additionally, Auranofin and α-Tocopheryl succinate affect the mitochondrial redox state and membrane potential, respectively. These changes can impair the environment required for optimal complex I activity, thus influencing LYRM5's functionality within the electron transport chain.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of the mitochondrial electron transport chain at complex I, where LYRM5 is implicated. Inhibition at this site disrupts electron flow, which directly inhibits LYRM5 function in electron transfer crucial for ATP production. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A mimics the effects of rotenone, directly inhibiting complex I of the mitochondrial electron transport chain. This inhibition consequently impacts LYRM5 by preventing its involvement in electron transfer within the respirasome. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
As a specific inhibitor of mitochondrial complex II, Carboxin indirectly inhibits LYRM5 by disrupting the overall electron transport chain, which can lead to a secondary inhibition of complex I function where LYRM5 is active. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
TTFA targets complex II, and its inhibition can lead to a compensatory reduction in complex I activity, thereby functionally inhibiting LYRM5 by reducing its role in electron transport. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $270.00 | 2 | |
Atovaquone blocks electron transfer at the ubiquinone binding site within complex III, resulting in back-pressure of electrons that can inhibit the upstream complex I where LYRM5 functions, thus indirectly inhibiting its activity. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
By binding to the Qi site of complex III of the mitochondrial electron transport chain, Antimycin A inhibits electron transfer, which can lead to a reduced function of upstream complex I components, including LYRM5. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain. This inhibition can cause a cascade effect that reduces the function of upstream complexes including complex I, and thus functionally inhibits LYRM5. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A inhibits ATP synthase (complex V). The resulting decrease in ATP production can indirectly inhibit LYRM5 by reducing the demand for its function in electron transport as part of complex I. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin inhibits thioredoxin reductase, which can alter the mitochondrial redox state. This alteration can indirectly inhibit LYRM5 by disturbing the redox-sensitive processes in complex I where LYRM5 is essential. | ||||||