Date published: 2026-4-24

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2-Thenoyltrifluoroacetone (CAS 326-91-0)

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Alternate Names:
4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione; 1-(2-Thenoyl)-3,3,3-trifluoroacetone; 2-(3-Oxo-4,4,4-trifluorobutanoyl)thiophene
Application:
2-Thenoyltrifluoroacetone is a reagent use to analyze metals
CAS Number:
326-91-0
Purity:
≥97%
Molecular Weight:
222.18
Molecular Formula:
C8H5F3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Thenoyltrifluoroacetone (TTFA) is a versatile compound with multiple roles as an inhibitor and chelating agent. It exhibits inhibitory effects on respiration in animals and bacteria by targeting specific enzyme complexes. In bacteria, it inhibits NADH fumarate reductase. 2-Thenoyltrifluoroacetone also demonstrates inhibition of photosystem II in plants and NADH-ubiquinone oxidoreductase in the Vibrio cholerae virus, leading to reduced production of cholera toxin. Furthermore, 2-Thenoyltrifluoroacetone serves as a chelator for various metals, including lanthanum, zirconium, hafnium, and neodymium. Its chelating properties enable it to form stable complexes with these metals. Overall, 2-Thenoyltrifluoroacetone plays a dual role as a chelating agent and an inhibitor of cellular respiration, exerting its effects through specific interactions with enzyme complexes and metal binding.


2-Thenoyltrifluoroacetone (CAS 326-91-0) References

  1. Magnetic field enhanced microextraction rate of europium(III) with 2-thenoyltrifluoroacetone and oxalate at dodecane-water interface.  |  Tsukahara, S., et al. 2004. Anal Sci. 20: 1515-21. PMID: 15566142
  2. Ionic liquid synergistic cation-exchange system for the selective extraction of lanthanum(III) using 2-thenoyltrifluoroacetone and 18-crown-6.  |  Hirayama, N., et al. 2008. Anal Sci. 24: 697-9. PMID: 18544855
  3. Solvent extraction of gallium(III) with 2-thenoyltrifluoroacetone.  |  Dhond, PV. and Khopkar, SM. 1976. Talanta. 23: 51-3. PMID: 18961800
  4. Synergistic extraction of lanthanoids(III) with 2-thenoyltrifluoroacetone and benzoic acid: thermodynamic parameters in the complexation in organic phases and the hydration.  |  Matsubayashi, I., et al. 2004. Talanta. 63: 625-33. PMID: 18969479
  5. Hybrid materials of lanthanide centers/functionalized 2-thenoyltrifluoroacetone/silicon-oxygen network/polymeric chain: coordination bonded assembly, physical characterization, and photoluminescence.  |  Qiao, XF. and Yan, B. 2009. Inorg Chem. 48: 4714-23. PMID: 19374368
  6. Covalently bonded assembly of lanthanide/silicon-oxygen network/polyethylene glycol hybrid materials through functionalized 2-thenoyltrifluoroacetone linkage.  |  Qiao, XF. and Yan, B. 2009. J Phys Chem B. 113: 11865-75. PMID: 19658417
  7. Photoactive europium(III) centered mesoporous hybrids with 2-thenoyltrifluoroacetone functionalized SBA-16 and organic polymers.  |  Li, Y. and Yan, B. 2010. Dalton Trans. 39: 2554-62. PMID: 20179848
  8. Synergistic effect of 18-crown-6 derivatives on chelate extraction of lanthanoids(III) into an ionic liquid with 2-thenoyltrifluoroacetone.  |  Okamura, H., et al. 2010. Anal Sci. 26: 607-11. PMID: 20467139
  9. Solvent effect of ionic liquids on the distribution constant of 2-thenoyltrifluoroacetone and its nickel(II) and copper(II) chelates and the evaluation of the solvent properties based on the regular solution theory.  |  Kidani, K. and Imura, H. 2010. Talanta. 83: 299-304. PMID: 21111137
  10. Transparent Layer Derived from Layered Europium Hydroxide Sensitized with 2-Thenoyltrifluoroacetone.  |  Wang, J., et al. 2016. J Nanosci Nanotechnol. 16: 5058-62. PMID: 27483871
  11. Surfactant-assisted emulsification dispersive liquid-liquid microextraction using 2-thenoyltrifluoroacetone as a chelating agent coupled with electrothermal atomic absorption spectrometry for the speciation of chromium in water and rice samples.  |  Dokpikul, N., et al. 2018. Food Chem. 246: 379-385. PMID: 29291862
  12. Europium(III) Complex-Functionalized SiO2@mTiO2 Nanospheres for Al3+-Modulated Multicolor Emission.  |  Bai, C., et al. 2021. Nanomaterials (Basel). 11: PMID: 34835650
  13. Synthesis, Optoelectronic and Photoluminescent Characterizations of Green Luminous Heteroleptic Ternary Terbium Complexes.  |  Dalal, A., et al. 2022. J Fluoresc. 32: 1019-1029. PMID: 35254626
  14. Inhibition of mitochondrial malate dehydrogenase by 2-thenoyltrifluoroacetone.  |  Gutman, M. and Hartstein, E. 1974. FEBS Lett. 49: 170-3. PMID: 4374393

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Thenoyltrifluoroacetone, 5 g

sc-251801
5 g
$37.00