Date published: 2025-12-11

1-800-457-3801

SCBT Portrait Logo
Seach Input

LYAG Inhibitors

LYAG inhibitors, short for Lysophosphatidylglycerol Acyltransferase inhibitors, belong to a distinct chemical class of compounds that play a crucial role in modulating lipid metabolism within biological systems. These inhibitors are characterized by their ability to specifically target and inhibit the activity of the enzyme lysophosphatidylglycerol acyltransferase (LYAG), which is a key enzyme involved in lipid biosynthesis. LYAG is responsible for catalyzing the acylation of lysophosphatidylglycerol (LPG) molecules, a crucial step in the biosynthesis of phosphatidylglycerol (PG), a major constituent of cell membranes. LYAG inhibitors are designed to interfere with this enzymatic process, thereby affecting the composition and integrity of cell membranes and leading to various physiological consequences. The chemical structure of LYAG inhibitors varies, but they typically possess specific functional groups and motifs that allow them to interact with the active site of the LYAG enzyme. By binding to the enzyme, these inhibitors disrupt its ability to acylate LPG, which in turn hinders the production of PG. This interference can have wide-ranging effects on cellular processes, as PG is not only a structural component of cell membranes but also plays a role in various cellular functions, including signal transduction and ion transport.

SEE ALSO...

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1-Deoxynojirimycin Hydrochloride

73285-50-4sc-201694
sc-201694A
sc-201694B
1 mg
10 mg
100 mg
$73.00
$150.00
$420.00
2
(0)

1-Deoxynojirimycin Hydrochloride exhibits unique interactions with glycosidases, acting as a competitive inhibitor that alters enzyme kinetics. Its structural conformation allows for specific binding to the active site, disrupting substrate recognition and catalysis. This compound's ability to modulate carbohydrate metabolism is linked to its influence on glycoprotein processing, showcasing its role in cellular signaling pathways and metabolic regulation.

Acarbose

56180-94-0sc-203492
sc-203492A
1 g
5 g
$222.00
$593.00
1
(1)

An oligosaccharide that mildly inhibits lysosomal alpha-glucosidase, mainly used to inhibit intestinal alpha-glucosidases.

N-(n-Nonyl)deoxynojirimycin

81117-35-3sc-219388
sc-219388A
5 mg
25 mg
$161.00
$627.00
(0)

N-(n-Nonyl)deoxynojirimycin demonstrates distinctive molecular behavior through its hydrophobic interactions, enhancing its affinity for lipid membranes. This compound's unique alkyl chain facilitates penetration into cellular environments, influencing membrane fluidity and permeability. Its structural features promote selective binding to specific carbohydrate structures, potentially altering glycan profiles and impacting cellular communication. The compound's kinetic properties suggest a nuanced role in modulating enzymatic activities related to glycosylation processes.

Castanospermine

79831-76-8sc-201358
sc-201358A
100 mg
500 mg
$180.00
$620.00
10
(1)

An indolizidine alkaloid inhibiting several glucosidases, including lysosomal alpha-glucosidase, by active site binding.

Deoxynojirimycin

19130-96-2sc-201369
sc-201369A
1 mg
5 mg
$72.00
$142.00
(0)

Found in mulberry leaves, DNJ is a potent inhibitor of glucosidases, including lysosomal alpha-glucosidase, through competitive inhibition.

Miglitol

72432-03-2sc-221943
10 mg
$158.00
1
(1)

Primarily an intestinal alpha-glucosidase inhibitor, also affects lysosomal alpha-glucosidase.

Conduritol B Epoxide (CBE)

6090-95-5sc-201356
sc-201356A
sc-201356B
sc-201356C
sc-201356D
sc-201356E
sc-201356F
5 mg
25 mg
50 mg
100 mg
250 mg
1 g
5 g
$76.00
$270.00
$490.00
$614.00
$1285.00
$5110.00
$20410.00
12
(1)

A potent inhibitor of lysosomal beta-glucosidase with activity against alpha-glucosidases, including lysosomal alpha-glucosidase.

Isofagomine D-Tartrate

957230-65-8sc-207767
sc-207767A
sc-207767C
sc-207767B
5 mg
10 mg
50 mg
25 mg
$379.00
$710.00
$1975.00
$1199.00
(1)

A glucosidase inhibitor affecting lysosomal alpha-glucosidase by altering enzyme conformation and function.

Deoxymannojirimycin hydrochloride

84444-90-6sc-201360
sc-201360A
1 mg
5 mg
$93.00
$239.00
2
(0)

A mannose analog inhibiting several glucosidases, including lysosomal alpha-glucosidase.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Known as a tyrosine kinase inhibitor, also inhibits lysosomal enzymes including alpha-glucosidase, likely through non-specific protein binding.