Lunatic Fringe Activators
Lunatic Fringe Activators, in essence, comprise chemicals known to interact, directly or indirectly, with the Lunatic Fringe (LFNG) protein. LFNG plays a pivotal role in the modulation of the Notch signaling pathway, a central mechanism in cellular communication and development.
The first notable group within this class are gamma-secretase inhibitors, such as DAPT, LY411575, DBZ, Compound E, and BMS-708163. The inhibition of gamma-secretase can lead to an accumulation of Notch, which in turn requires LFNG for subsequent modifications. Another influential compound is Valproic Acid, an HDAC inhibitor. Valproic Acid can amplify Notch signaling, thereby indirectly stimulating LFNG. Another compound, EDTA, which chelates calcium-an essential element for Notch signaling-can indirectly stimulate LFNG. Additionally, certain inhibitors like RO4929097 and SAHM1 target specific components of the Notch pathway, indirectly modulating LFNG. IMR-1 focuses on the Notch transcriptional activation complex, while FLI-06 impedes Notch signaling in the nucleus. Both compounds indirectly modulate LFNG activity by influencing various facets of the Notch pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A gamma-secretase inhibitor. Inhibition can lead to an accumulation of Notch, possibly requiring increased LFNG activity for modification. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase (HDAC) inhibitor. HDAC inhibition can enhance Notch signaling, which may indirectly stimulate LFNG. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Another gamma-secretase inhibitor. Similar to DAPT, it may lead to an indirect increase in LFNG activity through Notch accumulation. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $430.00 $1389.00 | 1 | |
Notch inhibitor targeting gamma-secretase, indirectly influencing LFNG activity via Notch modulation. | ||||||
SAHM1 | 2050906-89-1 | sc-507534 | 5 mg | $1435.00 | ||
Inhibitor of Mastermind-like1 (MAML1) transcriptional coactivator. By influencing Notch transcription, it can indirectly affect LFNG. | ||||||
FLI-06 | 313967-18-9 | sc-497529 | 5 mg | $82.00 | ||
Inhibits Notch signaling in the nucleus, indirectly influencing LFNG activity by modulating the Notch pathway. | ||||||
Compound E | 209986-17-4 | sc-221433 sc-221433A sc-221433B | 250 µg 1 mg 5 mg | $122.00 $335.00 $948.00 | 12 | |
A potent gamma-secretase inhibitor. Its effect on Notch can lead to an indirect modulation of LFNG. | ||||||
BMS-708163 | 1146699-66-2 | sc-364444 sc-364444A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
Targeting gamma-secretase and affecting Notch signaling, it may indirectly influence LFNG activity. | ||||||