LSR Inhibitors
The class of LSR inhibitors comprises a diverse array of chemicals that exert inhibitory effects on the LSR protein through various mechanisms. Atorvastatin, Mevastatin, Simvastatin, Lovastatin, and Pitavastatin belong to the class of HMG-CoA reductase inhibitors. These chemicals act by reducing cholesterol biosynthesis, thereby indirectly influencing LSR through cholesterol-dependent processes. Their impact on intracellular cholesterol levels modulates the function of LSR, which plays a crucial role in cholesterol transport and metabolism within cells. Fenofibrate, a PPARα agonist, and Ezetimibe, an NPC1L1 inhibitor, showcase indirect inhibition of LSR by targeting pathways associated with lipid metabolism. Fenofibrate acts through PPARα modulation, while Ezetimibe interferes with cholesterol absorption in the small intestine. Nifedipine, a calcium channel blocker, and Resveratrol, a polyphenol, exert their inhibitory effects by influencing intracellular calcium levels and SIRT1 activity, respectively, impacting pathways associated with LSR function.
Berberine, an AMPK modulator, and Diltiazem, a calcium channel blocker, indirectly inhibit LSR through pathways related to energy homeostasis and calcium-dependent processes. Fluvastatin, another HMG-CoA reductase inhibitor, contributes to this class by reducing cholesterol synthesis and, in turn, affecting LSR function. The intricate interplay of these diverse LSR inhibitors provides valuable insights into the regulatory networks governing LSR and its role in cellular processes, particularly those associated with lipid metabolism and cholesterol homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Atorvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a key enzyme in cholesterol biosynthesis. This inhibition reduces intracellular cholesterol levels, leading to downstream effects on LSR through cholesterol-dependent processes. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $77.00 $179.00 | 18 | |
Mevastatin, similar to Atorvastatin, is an HMG-CoA reductase inhibitor that decreases cholesterol synthesis. This indirect inhibition impacts LSR by modifying cellular cholesterol levels and related signaling pathways. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin, another HMG-CoA reductase inhibitor, reduces cholesterol biosynthesis, influencing LSR through cholesterol-dependent mechanisms. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, leading to decreased cholesterol production. This alteration in cellular cholesterol levels indirectly affects LSR, which plays a role in cholesterol transport and metabolism. | ||||||
Ezetimibe | 163222-33-1 | sc-205690 sc-205690A | 25 mg 100 mg | $96.00 $241.00 | 12 | |
Ezetimibe inhibits cholesterol absorption in the small intestine by targeting the Niemann-Pick C1-like 1 (NPC1L1) protein. This interference with cholesterol uptake indirectly impacts LSR by modulating intracellular cholesterol levels and related pathways. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that influences intracellular calcium levels. This perturbation in calcium signaling indirectly affects LSR expression and function, as LSR is known to be associated with calcium-dependent processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, modulates SIRT1 activity and downstream pathways. This indirect influence on LSR occurs through the SIRT1-dependent regulation of cellular processes associated with LSR function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine impacts AMP-activated protein kinase (AMPK) activity, influencing cellular energy homeostasis. This indirect modulation of LSR occurs through AMPK-related pathways, as LSR is involved in lipid metabolism and energy sensing. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker, alters intracellular calcium concentrations. This indirect impact on LSR arises through changes in calcium-dependent processes that LSR is involved in. | ||||||
Fluvastatin, Sodium Salt | 93957-55-2 | sc-202613 sc-202613A sc-202613B | 25 mg 50 mg 100 mg | $93.00 $138.00 $246.00 | 1 | |
Fluvastatin, an HMG-CoA reductase inhibitor, decreases cholesterol synthesis. By modifying intracellular cholesterol levels, Fluvastatin indirectly influences LSR activity, given its role in cholesterol transport and metabolism. | ||||||