LSm4 Inhibitors
LSm4 inhibitors encompass a diverse range of compounds largely anchored in the overarching realm of RNA metabolism, especially focusing on RNA polymerase activity and splicing. α-amanitin, Actinomycin D, DRB, and Cordycepin specifically inhibit RNA polymerase or truncate the ATP-dependent elongation process, which can subsequently impact the broader roles LSm4 plays in mRNA decay. Such inhibitions resonate through RNA metabolism, thereby indirectly affecting the operational scope of LSm4.
In a distinct subset, Pladienolide B, Spliceostatin A, Herboxidiene, Isoginkgetin, and Meayamycin B target the splicing machinery. Given that LSm4 is implicated in the splicing mechanism, inhibition of this process can disrupt the efficiency and specificity of RNA splicing events where LSm4 might have a role. It is worth noting that while these compounds do not target LSm4 directly, their modulation of the associated pathways or processes delineates a strategy to understand LSm4's functions better.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
RNA polymerase II inhibitor, affecting overall RNA metabolism which can indirectly impact LSm4 functions. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Intercalates DNA and inhibits RNA synthesis, influencing LSm4 indirectly. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II, potentially affecting LSm4-associated processes. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Truncated ATP analogue, inhibits mRNA elongation and can indirectly affect LSm4 functions. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
CDK9 inhibitor that blocks RNA polymerase II, indirectly affecting LSm4. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Spliceosome inhibitor, impacting splicing processes associated with LSm4. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceosome inhibitor, altering LSm4-associated RNA splicing. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Another spliceosome inhibitor, impacting LSm4 activities in splicing. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Inhibits splicing, affecting LSm4 functions. | ||||||