LRRC59 Inhibitors
These compounds are known to interact with various cellular transport mechanisms, which could influence the function of LRRC59 indirectly. However, the specificity and direct impact on LRRC59 would need to be confirmed through detailed biochemical and cellular studies.
The class of LRRC59 inhibitors, as described, does not refer to direct inhibitors but rather to compounds that affect the nuclear export and import pathways, where LRRC59 plays a role. Since LRRC59 is involved in the export of FGF1 and other cargoes that lack a classical nuclear export signal, inhibiting the nuclear export receptors or factors involved in this process could indirectly affect the function of LRRC59. Targeting these pathways requires a careful balance to avoid widespread disruption of cellular protein trafficking. The inhibitors listed might impact the cellular localization and function of various proteins, including but not limited to those directly interacting with or regulated by LRRC59.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Inhibits nuclear export by binding to exportin 1 (CRM1), which could indirectly affect the export functions associated with LRRC59. | ||||||
Ratjadone A, Synthetic | 163564-92-9 | sc-203234 | 2 µg | $168.00 | 2 | |
A natural compound that inhibits CRM1-dependent nuclear export, potentially influencing LRRC59-mediated export pathways. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $170.00 | ||
A selective inhibitor of nuclear export that targets exportin 1 (CRM1), potentially impacting LRRC59 functions. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Known as a glucocorticoid receptor antagonist, but it can also affect nuclear transport and may indirectly influence LRRC59 activity. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
An antineoplastic agent that intercalates into DNA and inhibits topoisomerase II, which might indirectly affect LRRC59's associated processes. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
A broad-spectrum antiparasitic agent that also modulates various ion channels and transporters, potentially influencing nuclear export processes associated with LRRC59. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that disrupts lysosomal function and could indirectly influence LRRC59-associated pathways. | ||||||