LPAAT-γ Activators
LPAAT-γ Activators encompass a range of chemical compounds that either serve as substrates or modulate the lipid environment, thereby enhancing the activity of LPAAT-γ in phospholipid biosynthesis and cellular signaling. The presence of fatty acyl-CoA derivatives like Palmitoyl-CoA, Oleoyl-CoA, and Arachidonoyl-CoA is pivotal, as they directly act as substrates in the LPAAT-γ catalyzed reaction, facilitating the acylation of LysoPA to form phosphatidic acid (PA). This reaction is central to membrane lipid synthesis and signaling lipid production, with each acyl-CoA variant contributing to the diversity of PA species and thus the functional versatility of LPAAT-γ. Beyond these direct substrates, LPAAT-γ's activity is also influenced by the cellular lipid milieu. Compounds such as Sphingosine 1-Phosphate (S1P) and Diacylglycerol (DAG) modulate lipid signaling pathways that intersect with those regulated by LPAAT-γ, indirectly enhancing its activity in PA synthesis. Similarly, alterations in membrane lipids like Phosphatidylinositol 4,5-Bisphosphate (PIP2), Phosphatidylserine (PS), and cholesterol can affect LPAAT-γ indirectly. These changes in membrane dynamics, fluidity, and lipid composition create a conducive environment for LPAAT-γ's enzymatic action.
Further, the availability of certain lipid components like Ethanolamine and Choline, integral to the synthesis of major phospholipids such as phosphatidylethanolamine and phosphatidylcholine, respectively, indirectly influences LPAAT-γ's function. The balance of these phospholipids in the membrane can affect LPAAT-γ's efficiency in catalyzing PA production. Moreover, Ceramide, a key sphingolipid, plays a role in modulating cellular signaling pathways and membrane properties. Fluctuations in ceramide levels can indirectly impact LPAAT-γ's role in phospholipid biosynthesis, highlighting the intricate interplay between different lipid species and signaling molecules in regulating LPAAT-γ's activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Arachidonoyl-CoA is involved in the acylation of LPA, mediated by LPAAT-γ. This specific acylation leads to the formation of arachidonoyl-containing PA, which plays a significant role in the synthesis of membrane lipids and signaling lipids. The presence of Arachidonoyl-CoA directly enhances LPAAT-γ's ability to produce functionally diverse PA molecules. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LysoPA is the direct substrate for LPAAT-γ in the synthesis of PA. By providing LysoPA, LPAAT-γ is catalytically active, leading to the production of phosphatidic acid, a precursor for various glycerophospholipids and a key signaling molecule. The availability of LysoPA is crucial for LPAAT-γ activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P influences signaling pathways that can indirectly increase the activity of LPAAT-γ. It engages in sphingolipid signaling, which intersects with phospholipid metabolism where LPAAT-γ operates. S1P can modulate the cellular lipid environment, indirectly enhancing the activity of LPAAT-γ in phospholipid biosynthesis. | ||||||
XL-184 free base | 849217-68-1 | sc-364657 sc-364657A | 5 mg 10 mg | $94.00 $208.00 | 1 | |
PIP2 is involved in membrane signaling and can indirectly influence LPAAT-γ activity. Changes in PIP2 levels affect membrane dynamics and lipid signaling pathways, which can alter the functional environment in which LPAAT-γ operates. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide participates in sphingolipid metabolism and can indirectly affect LPAAT-γ activity. Changes in ceramide levels can influence cellular signaling pathways and membrane properties, indirectly modulating LPAAT-γ's role in phospholipid biosynthesis. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol, a major component of cell membranes, indirectly affects LPAAT-γ activity. It influences membrane fluidity and lipid raft formation, which can impact the membrane-associated functions of LPAAT-γ in PA synthesis. | ||||||
Ethanolamine | 141-43-5 | sc-203042 sc-203042A sc-203042B | 25 ml 500 ml 2.5 L | $22.00 $56.00 $204.00 | 1 | |
Ethanolamine is a component of phosphatidylethanolamine (PE), a major phospholipid. Its availability can indirectly influence LPAAT-γ activity by affecting the overall phospholipid composition and metabolism, thus modifying LPAAT-γ's functional environment. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline, a component of phosphatidylcholine (PC), indirectly influences LPAAT-γ activity. Changes in choline availability can affect PC synthesis and overall membrane composition, thereby potentially modifying the functional context in which LPAAT-γ operates. | ||||||