LOC729855 Inhibitors
Wortmannin and LY333531, which target key enzymes such as PI3K and PKC, respectively. These enzymes play critical roles in the regulation of cell growth, survival, and differentiation, and their inhibition can lead to significant alterations in these cellular functions. Alsterpaullone, can inhibit CDKs, thus potentially affecting the cell cycle and transcriptional regulation. Similarly, U0126 and PD0325901 specifically inhibit MEK1/2, which are central components of the MAPK/ERK pathway, a pathway crucial for cell proliferation and differentiation. SP600125 and Gö 6983 disrupt JNK and PKC signaling, respectively, influencing inflammation and apoptosis-related processes.
Compounds like SB431542 and ZM-447439 target TGF-beta receptors and Aurora kinases, both of which are essential for various cellular processes including growth, apoptosis, and cell division. Thapsigargin, by inhibiting the SERCA pump, can cause disruptions in calcium signaling, which is vital for many cellular functions. Dorsomorphin offers a unique approach by inhibiting AMPK, which regulates energy balance, and by affecting BMP signaling, it can influence developmental pathways. MG132 disrupts protein turnover by inhibiting the proteasome, affecting protein degradation pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphatidylinositol 3-kinase (PI3K) inhibitor that can disrupt PI3K-dependent signaling pathways. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase (CDK) inhibitor that can impede cell cycle progression and transcription regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2 that can block the MAPK/ERK pathway, possibly affecting proteins regulated by these kinases. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK) that can modulate JNK-mediated signal transduction processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-beta receptor that can interfere with TGF-beta signaling and associated cellular processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor that can disrupt mitosis and cytokinesis by affecting spindle assembly and stability. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A protein kinase C (PKC) inhibitor that can alter PKC-mediated signaling pathways and related protein functions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitor that can perturb calcium homeostasis in cells. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $182.00 $736.00 | 28 | |
An inhibitor of AMP-activated protein kinase (AMPK) and BMP signaling that can impact cellular energy and developmental processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of proteins, potentially affecting protein levels and turnover. | ||||||